E-ISSN 2577-5669
 

Original Research 


Comparison of the Effect of Acetaminophen Suppository in Children 7 to 15 years before and after Tonsillectomy on Pain Relief

Reza Gharibi, Gholam-Ali Dashti Khavidaki.

Abstract
Introduction: tonsillectomy in children is associated with many complications such as severe postoperative pain. The analgesic effect of rectal acetaminophen has been demonstrated in various surgical procedures. The aim of this study was to compare the effect of acetaminophen suppository in children 7 to 15 years before and after tonsillectomy on pain relief.
Materials and Methods: In this clinical trial study, 100 children aged 7 to 15 years who were candidates for tonsillectomy were included in the study. Patients were randomly divided into two equal groups. After induction of anesthesia and intubation and 5 minutes before the start of surgery, group A received 40 mg / kg rectal acetaminophen suppository, and group B received the same dose of rectal acetaminophen suppository after surgery and just before extubation and immediately after discontinuation of anesthetic drugs. Patients were then compared in terms of pain and use of analgesic, 1, 3, 6, 12, and 24 hours after the surgery.
Results: In group A, 56% of patients were female and 44% male, and in group B, 52% were male and 48% female (P = 0.688). The mean age of patients in group A was 9.17 2.90 years and in group B was 9.5 2.49 years (P = 0.543). The mean pain score in each of 1, 3, 6, 12 and 24 hours was significantly lower in group A than in group B (P <0.05 in all cases). Also, the mean changes in pain 24 hours after surgery were significantly lower in group A than group B (P <0.001). Consumption of both oral (P = 0.041) and intravenous (P = 0.008) analgesics was significantly lower in group A than in group B.
Conclusion: Using rectal acetaminophen before tonsillectomy is a more effective way to reduce pain after tonsillectomy than using it after the surgery, which reduces the need for analgesics in these patients after surgery.

Key words: Adenotonsillectomy, Acetaminophen, Pain, Tonsil, Rectal.


 
ARTICLE TOOLS
Abstract
PDF Fulltext
How to cite this articleHow to cite this article
Citation Tools
Related Records
 Articles by Reza Gharibi
Articles by Gholam-Ali Dashti Khavidaki
on Google
on Google Scholar


How to Cite this Article
Pubmed Style

Reza Gharibi, Gholam-Ali Dashti Khavidaki. Comparison of the Effect of Acetaminophen Suppository in Children 7 to 15 years before and after Tonsillectomy on Pain Relief. J Complement Med Res. 2020; 11(3): 68-73. doi:10.5455/jcmr.2020.11.03.09


Web Style

Reza Gharibi, Gholam-Ali Dashti Khavidaki. Comparison of the Effect of Acetaminophen Suppository in Children 7 to 15 years before and after Tonsillectomy on Pain Relief. http://www.jocmr.com/?mno=10854 [Access: October 11, 2020]. doi:10.5455/jcmr.2020.11.03.09


AMA (American Medical Association) Style

Reza Gharibi, Gholam-Ali Dashti Khavidaki. Comparison of the Effect of Acetaminophen Suppository in Children 7 to 15 years before and after Tonsillectomy on Pain Relief. J Complement Med Res. 2020; 11(3): 68-73. doi:10.5455/jcmr.2020.11.03.09



Vancouver/ICMJE Style

Reza Gharibi, Gholam-Ali Dashti Khavidaki. Comparison of the Effect of Acetaminophen Suppository in Children 7 to 15 years before and after Tonsillectomy on Pain Relief. J Complement Med Res. (2020), [cited October 11, 2020]; 11(3): 68-73. doi:10.5455/jcmr.2020.11.03.09



Harvard Style

Reza Gharibi, Gholam-Ali Dashti Khavidaki (2020) Comparison of the Effect of Acetaminophen Suppository in Children 7 to 15 years before and after Tonsillectomy on Pain Relief. J Complement Med Res, 11 (3), 68-73. doi:10.5455/jcmr.2020.11.03.09



Turabian Style

Reza Gharibi, Gholam-Ali Dashti Khavidaki. 2020. Comparison of the Effect of Acetaminophen Suppository in Children 7 to 15 years before and after Tonsillectomy on Pain Relief. Journal of Complementary Medicine Research, 11 (3), 68-73. doi:10.5455/jcmr.2020.11.03.09



Chicago Style

Reza Gharibi, Gholam-Ali Dashti Khavidaki. "Comparison of the Effect of Acetaminophen Suppository in Children 7 to 15 years before and after Tonsillectomy on Pain Relief." Journal of Complementary Medicine Research 11 (2020), 68-73. doi:10.5455/jcmr.2020.11.03.09



MLA (The Modern Language Association) Style

Reza Gharibi, Gholam-Ali Dashti Khavidaki. "Comparison of the Effect of Acetaminophen Suppository in Children 7 to 15 years before and after Tonsillectomy on Pain Relief." Journal of Complementary Medicine Research 11.3 (2020), 68-73. Print. doi:10.5455/jcmr.2020.11.03.09



APA (American Psychological Association) Style

Reza Gharibi, Gholam-Ali Dashti Khavidaki (2020) Comparison of the Effect of Acetaminophen Suppository in Children 7 to 15 years before and after Tonsillectomy on Pain Relief. Journal of Complementary Medicine Research, 11 (3), 68-73. doi:10.5455/jcmr.2020.11.03.09





Most Viewed Articles
  • Role of Cyperus rotundus oil in decreasing hair growth
    GHADA FAROUK ABD EL-KAREAM
    J Intercult Ethnopharmacol. 2012; 1(2): 111-118
    » Abstract & References » doi: 10.5455/jice.20120626100304

  • Ethno-dentistry: popular medicinal plants used for dental diseases in India
    Amit Bhardwaj, Shalu Verma Bhardwaj
    J Intercult Ethnopharmacol. 2012; 1(1): 62-65
    » Abstract & References » doi: 10.5455/jice.20120322035152

  • Total phenolic, flavonoids and tannin contents in different extracts of Artemisia absinthium
    Rajeev Singh, Pawan Kumar Verma, Gagandeep Singh
    J Intercult Ethnopharmacol. 2012; 1(2): 101-104
    » Abstract & References » doi: 10.5455/jice.20120525014326

  • Antimicrobial and phytochemical evaluation of the leaf, stem bark and root extracts of Cyathula prostrata (L) Blume against some human pathogens
    Gideon Ikechukwu Ogu, Williams Omotola Tanimowo, Perpetua Ugonna Nwachukwu, Bright Esegbuyota Igere
    J Intercult Ethnopharmacol. 2012; 1(1): 35-43
    » Abstract & References » doi: 10.5455/jice.20120407085952

  • Herbal Antibacterials: A Review
    Chirag Modi, Shailesh Mody, Hitesh Patel, Ghanshyam Dudhatra, Avinash Kumar, Madhavi Awale
    J Intercult Ethnopharmacol. 2012; 1(1): 52-61
    » Abstract & References » doi: 10.5455/jice.20120207113423

  • Most Downloaded
  • Medicinal plants with potential anti-arthritic activity:
    Manjusha Choudhary, Vipin Kumar, Hitesh Malhotra, Surender Singh
    J Intercult Ethnopharmacol. 2015; 4(2): 147-179
    » Abstract & References » doi: 10.5455/jice.20150313021918

  • Total phenolic, flavonoids and tannin contents in different extracts of Artemisia absinthium
    Rajeev Singh, Pawan Kumar Verma, Gagandeep Singh
    J Intercult Ethnopharmacol. 2012; 1(2): 101-104
    » Abstract & References » doi: 10.5455/jice.20120525014326

  • Ethnobotanical Documentation of Traditional Knowledge about Medicinal Plants used by Indigenous People in Talash Valley of Dir Lower, Northern Pakistan
    Muhammad Tariq Khan, Latif Ahmad, Wajid Rashid
    J Intercult Ethnopharmacol. 2018; 7(1): 8-24
    » Abstract » doi: 10.5455/jice.20171011075112

  • Herbal Antibacterials: A Review
    Chirag Modi, Shailesh Mody, Hitesh Patel, Ghanshyam Dudhatra, Avinash Kumar, Madhavi Awale
    J Intercult Ethnopharmacol. 2012; 1(1): 52-61
    » Abstract & References » doi: 10.5455/jice.20120207113423

  • Antimicrobial and phytochemical evaluation of the leaf, stem bark and root extracts of Cyathula prostrata (L) Blume against some human pathogens
    Gideon Ikechukwu Ogu, Williams Omotola Tanimowo, Perpetua Ugonna Nwachukwu, Bright Esegbuyota Igere
    J Intercult Ethnopharmacol. 2012; 1(1): 35-43
    » Abstract & References » doi: 10.5455/jice.20120407085952

  • Most Cited Articles
  • Total phenolic, flavonoids and tannin contents in different extracts of Artemisia absinthium
    Rajeev Singh, Pawan Kumar Verma, Gagandeep Singh
    J Intercult Ethnopharmacol. 2012; 1(2): 101-104
    » Abstract & References » doi: 10.5455/jice.20120525014326
    Cited : 42 times [Click to see citing articles]

  • Potential antimalarials from African natural products: a review
    Bashir Lawal, Oluwatosin Kudirat Shittu, Adamu Yusuf Kabiru, Ali Audu Jigam, Maimuna Bello Umar, Eustace Bonghan Berinyuy, Blessing Uchenna Alozieuwa
    J Intercult Ethnopharmacol. 2015; 4(4): 318-343
    » Abstract & References » doi: 10.5455/jice.20150928102856
    Cited : 21 times [Click to see citing articles]

  • Medicinal plants with potential anti-arthritic activity:
    Manjusha Choudhary, Vipin Kumar, Hitesh Malhotra, Surender Singh
    J Intercult Ethnopharmacol. 2015; 4(2): 147-179
    » Abstract & References » doi: 10.5455/jice.20150313021918
    Cited : 20 times [Click to see citing articles]

  • Guava leaves polyphenolics-rich extract inhibits vital enzymes implicated in gout and hypertension in vitro
    Emmanuel Anyachukwu Irondi, Samson Olalekan Agboola, Ganiyu Oboh, Aline Augusti Boligon, Margareth Linde Athayde, Francis O. Shode
    J Intercult Ethnopharmacol. 2016; 5(2): 122-130
    » Abstract & References » doi: 10.5455/jice.20160321115402
    Cited : 20 times [Click to see citing articles]

  • Some pharmacological effects of cinnamon and ginger herbs in obese diabetic rats
    Mostafa Abbas Shalaby, Hamed Yahya Saifan
    J Intercult Ethnopharmacol. 2014; 3(4): 144-149
    » Abstract & References » doi: 10.5455/jice.20140818050741
    Cited : 19 times [Click to see citing articles]