E-ISSN 2577-5669
 

Original Research 


Computational Analysis of Oral Cancer Gene Expression Profile and Identification of MiRNAs and their Regulatory Hub Genes

Ariya S.S, Akhila Rachel James, Baby Joseph.

Abstract
Oral cancer is one of the major cancers causing death worldwide. Micro RNAs (miRNAs) are small RNA molecules, each capable of coding several genes. In oral cancer, many miRNAs were proven to be expressed in higher level in tumor samples when compared to normal. Iin this work, the miRNAs commonly expressed In oral cancer patients were analysed. The miRNAs hsa-miR-6514-3p’, ‘hsa-miR-34b-3p’, ‘hsa-miR-142-3p’, ‘hsa-miR-146b-5p’, ‘hsa-miR-451b’, ‘hsa-miR-519e’ and ‘hsa-miR-3591-3p were up-regulated in oral cancer patients. They coded for the genes AMN1, CUL1 and CDC14. The expression of these genes were related to oral cancer growth, progression and metastasis. Hence identifying drugs that could target these genes could help in reducing the oral cancer mortality by improving progression of patients.

Key words: miRNA, oral cancer, up-regulation, protein interaction network, master regulators


 
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Pubmed Style

Ariya S.S, Akhila Rachel James, Baby Joseph. Computational Analysis of Oral Cancer Gene Expression Profile and Identification of MiRNAs and their Regulatory Hub Genes. J Complement Med Res. 2020; 11(3): 154-159. doi:10.5455/jcmr.2020.11.03.19


Web Style

Ariya S.S, Akhila Rachel James, Baby Joseph. Computational Analysis of Oral Cancer Gene Expression Profile and Identification of MiRNAs and their Regulatory Hub Genes. http://www.jocmr.com/?mno=10958 [Access: October 11, 2020]. doi:10.5455/jcmr.2020.11.03.19


AMA (American Medical Association) Style

Ariya S.S, Akhila Rachel James, Baby Joseph. Computational Analysis of Oral Cancer Gene Expression Profile and Identification of MiRNAs and their Regulatory Hub Genes. J Complement Med Res. 2020; 11(3): 154-159. doi:10.5455/jcmr.2020.11.03.19



Vancouver/ICMJE Style

Ariya S.S, Akhila Rachel James, Baby Joseph. Computational Analysis of Oral Cancer Gene Expression Profile and Identification of MiRNAs and their Regulatory Hub Genes. J Complement Med Res. (2020), [cited October 11, 2020]; 11(3): 154-159. doi:10.5455/jcmr.2020.11.03.19



Harvard Style

Ariya S.S, Akhila Rachel James, Baby Joseph (2020) Computational Analysis of Oral Cancer Gene Expression Profile and Identification of MiRNAs and their Regulatory Hub Genes. J Complement Med Res, 11 (3), 154-159. doi:10.5455/jcmr.2020.11.03.19



Turabian Style

Ariya S.S, Akhila Rachel James, Baby Joseph. 2020. Computational Analysis of Oral Cancer Gene Expression Profile and Identification of MiRNAs and their Regulatory Hub Genes. Journal of Complementary Medicine Research, 11 (3), 154-159. doi:10.5455/jcmr.2020.11.03.19



Chicago Style

Ariya S.S, Akhila Rachel James, Baby Joseph. "Computational Analysis of Oral Cancer Gene Expression Profile and Identification of MiRNAs and their Regulatory Hub Genes." Journal of Complementary Medicine Research 11 (2020), 154-159. doi:10.5455/jcmr.2020.11.03.19



MLA (The Modern Language Association) Style

Ariya S.S, Akhila Rachel James, Baby Joseph. "Computational Analysis of Oral Cancer Gene Expression Profile and Identification of MiRNAs and their Regulatory Hub Genes." Journal of Complementary Medicine Research 11.3 (2020), 154-159. Print. doi:10.5455/jcmr.2020.11.03.19



APA (American Psychological Association) Style

Ariya S.S, Akhila Rachel James, Baby Joseph (2020) Computational Analysis of Oral Cancer Gene Expression Profile and Identification of MiRNAs and their Regulatory Hub Genes. Journal of Complementary Medicine Research, 11 (3), 154-159. doi:10.5455/jcmr.2020.11.03.19





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