E-ISSN 2577-5669
 

Original Research 


Anxiolytic and antidepressant-like effect of the ethanolic extract of Cassia tora seed in Swiss mice

Amit Kumar Shrivastava*, Laxmi Shrestha, Shanti Gurung, Bishal Joshi.

Abstract
Background: Cassia tora is a traditional herbal medicine has been used as an antihyperlipidemic, anti-inflammatory, anti-diabetic, expectorant, antioxidant effect, etc. Objectives: The aim of this study was to evaluate the anxiolytic and antidepressant effect of hydro-alcohol extract of Cassia tora in Swiss mice. Methods: Hydro-alcohol extract of Cassia tora was used for the evaluation of antidepressant, anxiolytic, biochemical estimation, skeletal muscle relaxant, and anoxic tolerance test. Results: The study showed that, in Locomotor activity, there was significant increase in no. of mobility count by Cassia tora extract as compared to negative control and diazepam treatment group (p<0.05, p<0.01). In forced swim test, there was a significant reduction in immobility at different time intervals with 400 mg/kg of Cassia tora extract as compared to negative control and was similar with imipramine treatment group (p<0.01). In a dose of 200 and 400 mg/kg of C. tora, there was a significant reduction in convulsion. At a dose of 400mg/kg, In Elevated Plus Maze test, the mean time spent in open arm increases and in close arm decreases compared to negative control group. Conclusion: Results indicated that Cassia tora extract has antidepressant, anxiolytic and anticonvulsant effect in adult Swiss mice.

Key words: Cassia tora, antidepressant, anxiolytic, Elevated Plus Maze, Forced swim test.


 
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How to Cite this Article
Pubmed Style

Amit Kumar Shrivastava, Laxmi Shrestha, Shanti Gurung, Bishal Joshi. Anxiolytic and antidepressant-like effect of the ethanolic extract of Cassia tora seed in Swiss mice. J Complement Med Res. 2020; 11(1): 1-8. doi:10.5455/jcmr.2020.11.01.01


Web Style

Amit Kumar Shrivastava, Laxmi Shrestha, Shanti Gurung, Bishal Joshi. Anxiolytic and antidepressant-like effect of the ethanolic extract of Cassia tora seed in Swiss mice. http://www.jocmr.com/?mno=115089 [Access: June 14, 2020]. doi:10.5455/jcmr.2020.11.01.01


AMA (American Medical Association) Style

Amit Kumar Shrivastava, Laxmi Shrestha, Shanti Gurung, Bishal Joshi. Anxiolytic and antidepressant-like effect of the ethanolic extract of Cassia tora seed in Swiss mice. J Complement Med Res. 2020; 11(1): 1-8. doi:10.5455/jcmr.2020.11.01.01



Vancouver/ICMJE Style

Amit Kumar Shrivastava, Laxmi Shrestha, Shanti Gurung, Bishal Joshi. Anxiolytic and antidepressant-like effect of the ethanolic extract of Cassia tora seed in Swiss mice. J Complement Med Res. (2020), [cited June 14, 2020]; 11(1): 1-8. doi:10.5455/jcmr.2020.11.01.01



Harvard Style

Amit Kumar Shrivastava, Laxmi Shrestha, Shanti Gurung, Bishal Joshi (2020) Anxiolytic and antidepressant-like effect of the ethanolic extract of Cassia tora seed in Swiss mice. J Complement Med Res, 11 (1), 1-8. doi:10.5455/jcmr.2020.11.01.01



Turabian Style

Amit Kumar Shrivastava, Laxmi Shrestha, Shanti Gurung, Bishal Joshi. 2020. Anxiolytic and antidepressant-like effect of the ethanolic extract of Cassia tora seed in Swiss mice. Journal of Complementary Medicine Research, 11 (1), 1-8. doi:10.5455/jcmr.2020.11.01.01



Chicago Style

Amit Kumar Shrivastava, Laxmi Shrestha, Shanti Gurung, Bishal Joshi. "Anxiolytic and antidepressant-like effect of the ethanolic extract of Cassia tora seed in Swiss mice." Journal of Complementary Medicine Research 11 (2020), 1-8. doi:10.5455/jcmr.2020.11.01.01



MLA (The Modern Language Association) Style

Amit Kumar Shrivastava, Laxmi Shrestha, Shanti Gurung, Bishal Joshi. "Anxiolytic and antidepressant-like effect of the ethanolic extract of Cassia tora seed in Swiss mice." Journal of Complementary Medicine Research 11.1 (2020), 1-8. Print. doi:10.5455/jcmr.2020.11.01.01



APA (American Psychological Association) Style

Amit Kumar Shrivastava, Laxmi Shrestha, Shanti Gurung, Bishal Joshi (2020) Anxiolytic and antidepressant-like effect of the ethanolic extract of Cassia tora seed in Swiss mice. Journal of Complementary Medicine Research, 11 (1), 1-8. doi:10.5455/jcmr.2020.11.01.01