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Study of antinociceptive and anti-inflammatory activities of certain Iranian medicinal plants

Fariba Sharififar, Payam Khazaeli, Narguess Alli, Elham Talebian, Raheleh Zarehshahi, Shivasadat Amiri.

Cited by (5)

Abstract
Aim: Four medicinal plants of Trigonella foenum-graecum, Zhumeria majdae, Achillea wilhelsii and Viola tricolor are traditionally used in Iran as analgesic and for treatment of inflammatory disorders. At the present atudy, the antinociceptive and anti-inflammatory effects of these plants have been studied.
Methods: The antinociceptive and anti-inflammatory activity of methanol extracts of tested plants were evaluated using hot-plate and carrageenan-induced edema methods respectively. The plant extracts were studied by i.p administration at three doses of 100, 200 and 400mg/kg.
Results: In the hot-plate test, the extracts of T. foeunm-graecum (100 mg/kg) and Z. majdae (200 and 400m g/kg) significantly increased the tolerance to pain in female albino mice in comparison to control. The administration of T. foenum-graecum at doses of 100 and 200mg/kg and V. tricolor (400mg/kg) significantly reduced the paw edema in male rat which measured in all the times of observation after carrageenan administration in comparison to control and reference (Ibuprofen, 400mg/kg).
Conclusions: The present work comparatively demonstrated considerable antinociceptive and anti inflammatory effect of all of the tested plants especially T. foeunm-graecum. The results here confirm traditional uses of T. foeunm-graecum both as analgesic or anti inflammatory agents.

Key words: Antinociceptive, Hot-Plate, Carrageenan-Induced edema, Anti inflammatory, Fenugreek


 
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REFERENCES
1. Amin G. Iranian Traditional Medicinal Plants. Tehran: Iranian Research Institute of medicinal plants Press, 1997.
2. Zargari A. Medicinal Plants. Tehran: Tehran University Publication., 1972.
3. Sharma R, Raghuram T, Rao N. Effects of fenugreek seeds on blood glucose and serum lipid in type І diabetes. Eur J Clin Nutr. 1990; 44 (4): 301-6. [Pubmed]   
4. Ajabnoor M, Tilmisany A. Effect of Trigonella foenum-graecum on blood glucose levels in normal and alloxan-diabetic mice. J Ethnopharmacol. 1998; 22: 45-9. [DOI via Crossref]   
5. El-Sokkary A, Ghoneim M. Effect of plants antioxidants in retarding the oxidative deterioration of Samna (Ghee). Indian Journal of Dairy Science. 1951; 4: 123-28.
6. Bouaziz E. Veterinary drugs. French Demande. 1976; 20: 4-8.
7. Rechinger K. Flroa Iranica. Verlagesanstalt: Akademische Druck, 1989.
8. Aynechi Y. Pharmacognosy and Iranian Medicinal Plants. Tehran: Tehran University Press, 1992.
9. Sharififar F, Mozaffarian V, Moshafi M, Dehghan-Nudeh G, Parandeh-Rezvani J, Mahdavi Z. Chemical compostion and biological activities of of Zhumeria majdae Resh. f.& Wendelb. Jundishapur Journal of Natural Pharmaceutical Products. 2008; 3: 8-18.
10. Etman M, Hassan A, Atta A, Fahmy G, Boselah N. Phytochemical and pharmacological studies on Achillea santolina. Egyptian Journal of Veterinary Science. 1987; 24: 181-9.
11. Sharififar F, Pournourmohammadi S, Arabnejad M. Immunomodulatory activity of aqueous extract of Achillea wilhelmsii C. Koch in mice. Indian Jurnal of Experimental Biology. 2009; 47(8): 668-71. [Pubmed]   
12. Witkowska-Banaszczak E, Bylka W, Matławska I, Goślińska O, Muszyński Z. Antimicrobial activity of Viola tricolor herb. Fitoterapia. 2005; 76: 458-61. [DOI via Crossref]    [Pubmed]   
13. Vukics V, Kery A, Bonn GK, al. e. Major flavonoid components of heartsease (Viola tricolor L.) and their antioxidant activities. Anal Bioanal Chem. 2008; 390 (7): 1917-25. [DOI via Crossref]    [Pubmed]   
14. Sharififar F, Khazaeli P, Alli N. In vivo evaluation of anti-inflammatory activity of topical preparations from Fenugreek (Trigonella foenum-graecum L.) seeds in a cream base. Iranian Journal of Pharmaceutical Sciences. 2009; 5: 157-62.
15. Adzu B, Amos S, Kapu S, Gamaniel K. Anti-inflammatory and anti-nociceptive effects of Sphaeranthus senegalensis. Journal of Ethnopharmacology. 2003; 84(2-3): 169-73. [DOI via Crossref]   
16. Winter C, Risley E, Nuss G. Carrageenan-induced oedema in hind paw of the rats as an assay for anti-inflammatory drugs. Proc Soc Exp Biol Med. 1962; 11: 544-7.
17. Shargel L, Yu ABC. 1999 Applied Biopharmaceutics and Pharmacokinetics 4th ed.: Appleton & Lange. Stamford, CT ISBN 0-8385-0278-4.
18. Biswal S, Das M, Nayak P. Antinociceptive activity of seeds of Trigonella foenum graecum in rats. Indian Journal of Physiol Pharmacol. 2003; 47: 479-80. [Pubmed]   
19. Bars DL, Gozariu M, Cadden S. Animal models of nociception. Pharmacological Reviews. 2001; 53: 597-652. [Pubmed]   
20. Swain A, Dutton S, Truswell A. Salicylates in foods. Journal of American Dietary Association. 1985; 85(8): 950-60. [Pubmed]   
21. Kamal R, Yadav R. Flavonoids from Trigonella polycerta in-vivo and in-vitro. Journal of Phytological Research 1991; 4:161-5.
22. Peana A, D'Aquila P, Chessa M, Moretti M, Serra G, Pippia P. (-) Linalool produces antinociception in two experimental models of pain. European Journal of Pharmacology. 2003; 460: 37-41. [DOI via Crossref]   
23. Hosseinzadeh H, Parvardeh H, Nassiri-Asl M, Mansouri S. Intra cerebro ventricular administration of thymoquinone, the major constituent of Nigella sativa seeds, suppresses epileptic seizures in rats. Medicinal Science Monitoring. 2005; 11:BR106-10. [Pubmed]   
24. Garcia-Pastor P, Randazzo A, Gomez-Paloma L, Alcaraz M, Paya M. Effects of petrosaspongiolide M, a novel phospholipase A2 inhibitor, on acute and chronic inflammation. J Pharmacol Exp Ther 1999; 289:166-72. [Pubmed]   
25. Rao Y, Fang S, Tzeng Y. Anti-inflammatory activities of flavonoids isolated from Caesalpinia pulcherrima. Journal of Ethnopharmacology. 2005;100 (3):249-53. [DOI via Crossref]    [Pubmed]   
26. Thakur A, Sarvaiya J, Bhavsar S, Malik J. Studies on the anti inflammatory activities of Trigonella in rats. 75 ed. Bombay: Update Ayurveda, 1994.
27. Pandian S, Anuradha C, Viswanathan P. Gastroprotective effect of fenugreek seeds (Trigonella foenum-graecum) on experimental gastric ulcer in rats. J Ethnopharmacol. 2002;81:393-7. [DOI via Crossref]   
28. Klövekorn W, Tepe A, Danesch U. A randomized, double-blind, vehicle-controlled, half-side comparison with a herbal ointment containing Mahonia aquifolium, Viola tricolor and Centella asiatica for the treatment of mild-to-moderate atopic dermatitis. International Journal of Clinical Pharmacology and Therapeutics 2007;45(11):583-91. [DOI via Crossref]    [Pubmed]   

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How to Cite this Article
Pubmed Style

Sharififar F, Khazaeli P, Alli N, Talebian E, Zarehshahi R, Amiri S. Study of antinociceptive and anti-inflammatory activities of certain Iranian medicinal plants. J Intercult Ethnopharmacol. 2012; 1(1): 19-24. doi:10.5455/jice.20120227104636



Web Style

Sharififar F, Khazaeli P, Alli N, Talebian E, Zarehshahi R, Amiri S. Study of antinociceptive and anti-inflammatory activities of certain Iranian medicinal plants. www.scopemed.org/?mno=14103 [Access: November 18, 2017]. doi:10.5455/jice.20120227104636



AMA (American Medical Association) Style

Sharififar F, Khazaeli P, Alli N, Talebian E, Zarehshahi R, Amiri S. Study of antinociceptive and anti-inflammatory activities of certain Iranian medicinal plants. J Intercult Ethnopharmacol. 2012; 1(1): 19-24. doi:10.5455/jice.20120227104636



Vancouver/ICMJE Style

Sharififar F, Khazaeli P, Alli N, Talebian E, Zarehshahi R, Amiri S. Study of antinociceptive and anti-inflammatory activities of certain Iranian medicinal plants. J Intercult Ethnopharmacol. (2012), [cited November 18, 2017]; 1(1): 19-24. doi:10.5455/jice.20120227104636



Harvard Style

Sharififar, F., Khazaeli, P., Alli, N., Talebian, E., Zarehshahi, R. & Amiri, S. (2012) Study of antinociceptive and anti-inflammatory activities of certain Iranian medicinal plants. J Intercult Ethnopharmacol, 1 (1), 19-24. doi:10.5455/jice.20120227104636



Turabian Style

Sharififar, Fariba, Payam Khazaeli, Narguess Alli, Elham Talebian, Raheleh Zarehshahi, and Shivasadat Amiri. 2012. Study of antinociceptive and anti-inflammatory activities of certain Iranian medicinal plants. Journal of Intercultural Ethnopharmacology, 1 (1), 19-24. doi:10.5455/jice.20120227104636



Chicago Style

Sharififar, Fariba, Payam Khazaeli, Narguess Alli, Elham Talebian, Raheleh Zarehshahi, and Shivasadat Amiri. "Study of antinociceptive and anti-inflammatory activities of certain Iranian medicinal plants." Journal of Intercultural Ethnopharmacology 1 (2012), 19-24. doi:10.5455/jice.20120227104636



MLA (The Modern Language Association) Style

Sharififar, Fariba, Payam Khazaeli, Narguess Alli, Elham Talebian, Raheleh Zarehshahi, and Shivasadat Amiri. "Study of antinociceptive and anti-inflammatory activities of certain Iranian medicinal plants." Journal of Intercultural Ethnopharmacology 1.1 (2012), 19-24. Print. doi:10.5455/jice.20120227104636



APA (American Psychological Association) Style

Sharififar, F., Khazaeli, P., Alli, N., Talebian, E., Zarehshahi, R. & Amiri, S. (2012) Study of antinociceptive and anti-inflammatory activities of certain Iranian medicinal plants. Journal of Intercultural Ethnopharmacology, 1 (1), 19-24. doi:10.5455/jice.20120227104636





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