E-ISSN 2146-8397 |
 

Original Research Open Access


NaCl stress-induced changes in the essential oil quality and abietane diterpene yield and composition in common sage

Taieb Tounekti, Habib Khemira.

Cited by (2)

Abstract
Aim: The purpose of this study was to evaluate how increasing NaCl salinity in the medium can affects the essential oils (EOs) composition and phenolic diterpene content and yield in leaves of Salvia officinalis L. The protective role of such compounds against NaCl stress was also argued with regard to some physiological characteristics of the plant (water and ionic relations as well as the leaf gas exchanges). Materials and Methods: Potted plants were exposed to increasing NaCl concentrations (0, 50, 75 and 100 mM) for 4 weeks during July 2012. Replicates from each treatment were harvested after 0, 2, 3 and 4 weeks of adding salt to perform physiological measurements and biochemical analysis. Results: Sage EOs were rich in manool, viridiflorol, camphor, and borneol. Irrigation with a solution containing 100 mM NaCl for 4 weeks increased considerably 1.8-cineole, camphor and β-thujone concentrations, whereas lower concentrations (50 and 75 mM) had no effects. On the contrary, borneol and viridiflorol concentrations decreased significantly under the former treatment, while manool and total fatty acid concentrations were not affected. Leaf extracts contained also several diterpenes such as carnosic acid (CA), carnosol (CAR) and 12-О-methoxy carnosic acid (MCA). The concentrations and total contents of CA and MCA increased after 3 weeks of irrigation with 75 or 100 mM NaCl. The 50 mM NaCl had no effect on these diterpenes. Our results suggest a protective role for CA against salinity stress. Conclusion: This study may provide ways to manipulate the concentration and yield of some phenolic diterpenes and EOs in sage. In fact soil salinity may favour a directional production of particular components of interest.

Key words: Salinity, plant nutrition, carnosic acid, antioxidants, essential oil quality


 
ARTICLE TOOLS
Abstract
HTML Fulltext
PDF Fulltext
Print this article Print this Article
How to cite this articleHow to cite this article
Export to
Export to
Related Records
 Articles by Taieb Tounekti
Articles by Habib Khemira
on Google
on Google Scholar
Article Statistics
 Viewed: 1709
Downloaded: 369
Cited: 2

REFERENCES
1. Ben Taarit M, Msaada K, Hosni K, Hammami M, Kchouk ME, Marzouk M, et al. Plant growth, essential oil yield and composition of sage (Salvia offcinalis L.) fruits cultivated under salt stress conditions. Ind Crop Prod 2009;30:333-7. [DOI via Crossref]   
2. Tounekti T, Munné-Bosch S, Vadel AM, Chtara C, Khemira H. Influence of ionic interactions on essential oil and phenolic diterpene composition of Dalmatian sage (Salvia officinalis L.). Plant Physiol Biochem 2010;48:813-21. [DOI via Crossref]    [Pubmed]   
3. Aziz EE, Sabry RM, Ahmed SS. Plant growth and essential oil production of sage (Salvia officinalis L.) and curly-leafed parsley (Petroselinum crispum ssp. crispum L.) cultivated under salt stress conditions. World Appl Sci J 2013;28:785-96.
4. Leung AY, Foster S. Encyclopedia of Common Natural Ingredients Used in Food, Drugs, and Cosmetics. 2nd ed. New York: John Wiley & Sons, Inc.; 1996.
5. Chnnusamy V, Jagendorf A, Zhu J. Understanding and improving salt tolerance in plants. Crop Sci 2005;45:437-48. [DOI via Crossref]   
6. Tounekti T, Vadel AM, Bedoui A, Khemira H. NaCl stress affects growth and essential oil composition in rosemary (Rosmarinus officinalis L.). J Hortic Sci Biotechnol 2008;83:267-73.
7. Raal A, Orav A, Arak E. Composition of the essential oil of Salvia officinalis L. from various European countries. Nat Prod Res 2007;21:406-11. [DOI via Crossref]    [Pubmed]   
8. Perry NB, Anderson RE, Brennan NJ, Douglas MH, Heaney AJ, McGimpsey JA, et al. Essential oils from dalmatian sage (Salvia officinalis l.): Variations among individuals, plant parts, seasons, and sites. J Agric Food Chem 1999;47:2048-54. [DOI via Crossref]    [Pubmed]   
9. Schwarz K, Ternes W. Antioxidative constituents of Rosmarinus officinalis and Salvia officinalis: I. isolation of carnosic acid and formation of other phenolic diterpenes. Z Leben Unters Forsch 1992;195:99-103. [DOI via Crossref]   
10. Brückner K, Božic D, Manzano D, Papaefthimiou D, Pateraki I, Scheler U, et al. Characterization of two genes for the biosynthesis of abietane-type diterpenes in rosemary (Rosmarinus officinalis) glandular trichomes. Phytochemistry 2014;101:52-64. [DOI via Crossref]    [Pubmed]   
11. Munné-Bosch S, Alegre L. Subcellular compartmentation of the diterpene carnosic acid and its derivatives in the leaves of rosemary. Plant Physiol 2001;125:1094-102. [DOI via Crossref]    [Pubmed]    [PMC Free Fulltext]   
12. Munné-Bosch S, Schwarz K, Alegre L. Enhanced formation of alphatocopherol and highly oxidized abietane diterpenes in water-stressed rosemary plants. Plant Physiol 1999;121:1047-052. [DOI via Crossref]    [Pubmed]    [PMC Free Fulltext]   
13. Thorsen MA, Hildebrandt KS. Quantitative determination of phenolic diterpenes in rosemary extracts. Aspects of accurate quantification. J Chromatogr A 2003;995:119-25. [DOI via Crossref]   
14. Paris A, Strukelj B, Renko M, Turk V, Pukl M, Umek A, et al. Inhibitory effect of carnosic acid on HIV-1 protease in cell-free assays [corrected]. J Nat Prod 1993;56:1426-30. [DOI via Crossref]    [Pubmed]   
15. Rau O, Wurglics M, Paulke A, Zitzkowski J, Meindl N, Bock A, et al. Carnosic acid and carnosol, phenolic diterpene compounds of the labiate herbs rosemary and sage, are activators of the human peroxisome proliferator-activated receptor gamma. Planta Med 2006;72:881-7. [DOI via Crossref]    [Pubmed]   
16. Fischedick JT, Standiford M, Johnson DA, Johnson JA. Structure activity relationship of phenolic diterpenes from Salvia officinalis as activators of the nuclear factor E2-related factor 2 pathway. Bioorg Med Chem 2013;21:2618-22. [DOI via Crossref]    [Pubmed]    [PMC Free Fulltext]   
17. Tounekti T, Munné-Bosch S. Enhanced phenolic diterpenes antioxidant levels through non-transgenic approaches. Crit Rev Plant Sci 2012;31:505-19. [DOI via Crossref]   
18. del Ba-o MJ, Lorente J, Castillo J, Benavente-García O, del Río JA, Ortu-o A, et al. Phenolic diterpenes, flavones, and rosmarinic acid distribution during the development of leaves, flowers, stems, and roots of Rosmarinus officinalis. Antioxidant activity. J Agric Food Chem 2003;51:4247-53. [DOI via Crossref]    [Pubmed]   
19. Abreu ME, Muller M, Alegre L, Munne-Bosch S. Phenolic diterpenes and α-tocopherol contents in leaf extracts of 60 Salvia species. J Sci Food Agric 2008;88:2648-53. [DOI via Crossref]   
20. Tounekti T, Vadel AM, Ennajeh M, Khemira H, Munné-Bosch S. Ionic interactions and salinity affect monoterpene and phenolic diterpene composition in rosemary (Rosmarinus officinalis). J Plant Nutr Soil Sci 2011;174:504-14. [DOI via Crossref]   
21. El-Keltawi NE, Croteau R. Salinity depression of growth and essential oil formation in spearmint and marjoram and its reversal by foliar applied cytokinin. Phytochemistry 1987;26:1333-4. [DOI via Crossref]   
22. Heuer B, Yaniv Ravina I. Effect of late salinization of chia (Salvia hispanica), stock (Matthiolatri cuspidata) and evening primrose (Oenothera abiennis) on their oil content and quality. Ind Crop Prod 2002;15:162-7. [DOI via Crossref]   
23. Maas EV, Hoffman GJ. Crop salt tolerance - current assessment. J Irrigation Drainage Div ASCE 1977;103:115-34.
24. Delfine S, Alvino A, Villani MC, Loreto F. Restrictions to carbon dioxide conductance and photosynthesis in spinach leaves recovering from salt stress Plant Physiol 1999;119:1101-6. [DOI via Crossref]    [Pubmed]    [PMC Free Fulltext]   
25. Loreto F, Centritto M, Chartzoulakis K. Photosynthetic limitations in olive cultivars with different sensitivity to salt stress. Plant Cell Environ 2003;26:595-601. [DOI via Crossref]   
26. Ben Taarit M, Msaada K, Hosni K, Marzouk B. Changes in fatty acid and essential oil composition of sage (Salvia officinalis L.) leaves under NaCl stress. Food Chem 2010;9:951-6. [DOI via Crossref]   
27. Maric S, Maksimovic M, Milos M. The impact of the locality altitudes and stages of development on the volatile constituents of Salvia officinalis L. from Bosnia and herzegovina. J Essent Oil Res 2006;18:178-80. [DOI via Crossref]   
28. Bernotiene G, Nivinskiene O, Butkiene R, Mockute D. Essential oil composition variability in sage (Salvia officinalis L.). Chemija 2007;18:38-43.
29. Giannouli AL, Kintzios SE. Essential oils of Salvia spp: Examples of intra-specific and seasonal variation. In: Kintzios SE, editor. Sage: The Genus Salvia. Amsterdam: Harwood Academic Publishers; 2000. p. 69-80.
30. Croteau R, El-Bialy H, Dehal SS. Metabolism of monoterpenes: Metabolic fate of (+)-camphor in sage (Salvia officinalis). Plant Physiol 1987;84:643-8. [DOI via Crossref]    [Pubmed]    [PMC Free Fulltext]   
31. Senatore F, Arnold NA, Piozzi F, Formisano C. Chemical composition of the essential oil of Salvia microstegia Boiss. et Balansa growing wild in Lebanon. J Chromatogr A 2006;1108:276-8. [DOI via Crossref]    [Pubmed]   
32. Özek G, Özek T, Iþcan G, Baþer KH, Hamzaoglu E, Duran A. Comparison of hydrodistillation and microdistillation methods for the analysis of fruit volatiles of Prangos pabularia Lindl., and evaluation of its antimicrobial activity. S Afr J Bot 2007;73:563-9. [DOI via Crossref]   
33. Liang Q, Liang Z, Wang J, Xu W. Essential oil composition of Salvia miltiorrhiza flower. Food Chem 2009;113:592-4. [DOI via Crossref]   
34. Simon JE, Bubenheim DR, Joly RJ, Charles DJ. Water stress induced alterations in essential oil content and composition of sweet basil. J Essent Oil Res 1992;4:71-5. [DOI via Crossref]   
35. Neffati M, Marzouk B. Changes in essential oil and fatty acid composition in coriander (Coriandrum sativum l.) leaves under saline conditions. Ind Crop Prod 2008;28:137-42. [DOI via Crossref]   
36. Hendawy SF, Khalid KA. Response of sage (Salvia officinalis L.) plants to zinc application under different salinity levels. J Appl Sci Res 2005;1:147-55.
37. Khalid KH. Influence of water stress on growth, essential oil, and chemical composition of herbs (Ocimum Sp.). Int Agrophysics 2006;20:289-96.
38. Burbott AJ, Loomis WD. Evidence for metabolic turnover of monoterpenes in peppermint. Plant Physiol 1969;44:173-9. [DOI via Crossref]   
39. Munné-Bosch S, Alegre L. Drought-induced changes in the redox state of α-tocopherol, ascorbate and the diterpene carnosic acid in chloroplasts of Labiatae species differing in carnosic acid contents. Plant Physiol 2003;131:1816-25. [DOI via Crossref]    [Pubmed]    [PMC Free Fulltext]   
40. Putievsky E, Ravid U, Sanderovich D. Morphological observations and essential oils of sage (Salvia officinalis L.) under cultivation. J Essent Oil Res 1992;4:291-3. [DOI via Crossref]   
41. Hidalgo P, Ubera J, Tena M, Valcárcel M. Determination of carnosic acid in wild and cultivated Rosmarinus officinalis. J Agri Food Chem 1998;46:2624-7. [DOI via Crossref]   
42. Munné-Bosch S, Alegre L, Schwarz K. The formation of phenolic diterpenes in Rosmarinus officinalis L. under Mediterranean climate. Eur Food Res Technol 2000;210:263-7. [DOI via Crossref]   
43. Byun-McKay A, Godard KA, Toudefallah M, Martin DM, Alfaro R, King J, et al. Wound-induced terpene synthase gene expression in Sitka spruce that exhibit resistance or susceptibility to attack by the white pine weevil. Plant Physiol 2006;140:1009-21. [DOI via Crossref]    [Pubmed]    [PMC Free Fulltext]   
44. Kutuk C, Cayci G, Heng LK. Effects of increasing salinity and N-15 labelled urea levels on growth, N uptake, and water use efficiency of young tomato plants. Aust J Soil Res 2004;42:345-51. [DOI via Crossref]   
45. Boelens MH. Essential oils and aroma chemicals from Eucalyptus globulus Labill. Perfum Flavor 1985;9:1-14.
46. Areias F, Valentão P, Andrade PB, Ferreres F, Seabra RM. Flavonoids and phenolic acids of sage: Influence of some agricultural factors. J Agric Food Chem 2000;48:6081-4. [DOI via Crossref]    [Pubmed]   

This Article Cited By the following articles

How Essential Oil Content and Composition Fluctuate in German Chamomile Flowers During the Day?
Journal of Essential Oil Bearing Plants 2017; 20(3): 622.

1
 
Essential oils, amino acids and polyphenols changes in salt-stressed Thymus vulgaris exposed to open–field and shade enclosure
Industrial Crops and Products 2016; 91(): 223.

2
 

How to Cite this Article
Pubmed Style

Tounekti T, Khemira H. NaCl stress-induced changes in the essential oil quality and abietane diterpene yield and composition in common sage. J Intercult Ethnopharmacol. 2015; 4(3): 208-216. doi:10.5455/jice.20150405064135



Web Style

Tounekti T, Khemira H. NaCl stress-induced changes in the essential oil quality and abietane diterpene yield and composition in common sage. www.scopemed.org/?mno=179278 [Access: November 18, 2017]. doi:10.5455/jice.20150405064135



AMA (American Medical Association) Style

Tounekti T, Khemira H. NaCl stress-induced changes in the essential oil quality and abietane diterpene yield and composition in common sage. J Intercult Ethnopharmacol. 2015; 4(3): 208-216. doi:10.5455/jice.20150405064135



Vancouver/ICMJE Style

Tounekti T, Khemira H. NaCl stress-induced changes in the essential oil quality and abietane diterpene yield and composition in common sage. J Intercult Ethnopharmacol. (2015), [cited November 18, 2017]; 4(3): 208-216. doi:10.5455/jice.20150405064135



Harvard Style

Tounekti, T. & Khemira, H. (2015) NaCl stress-induced changes in the essential oil quality and abietane diterpene yield and composition in common sage. J Intercult Ethnopharmacol, 4 (3), 208-216. doi:10.5455/jice.20150405064135



Turabian Style

Tounekti, Taieb, and Habib Khemira. 2015. NaCl stress-induced changes in the essential oil quality and abietane diterpene yield and composition in common sage. Journal of Intercultural Ethnopharmacology, 4 (3), 208-216. doi:10.5455/jice.20150405064135



Chicago Style

Tounekti, Taieb, and Habib Khemira. "NaCl stress-induced changes in the essential oil quality and abietane diterpene yield and composition in common sage." Journal of Intercultural Ethnopharmacology 4 (2015), 208-216. doi:10.5455/jice.20150405064135



MLA (The Modern Language Association) Style

Tounekti, Taieb, and Habib Khemira. "NaCl stress-induced changes in the essential oil quality and abietane diterpene yield and composition in common sage." Journal of Intercultural Ethnopharmacology 4.3 (2015), 208-216. Print. doi:10.5455/jice.20150405064135



APA (American Psychological Association) Style

Tounekti, T. & Khemira, H. (2015) NaCl stress-induced changes in the essential oil quality and abietane diterpene yield and composition in common sage. Journal of Intercultural Ethnopharmacology, 4 (3), 208-216. doi:10.5455/jice.20150405064135





Most Viewed Articles
  • Role of Cyperus rotundus oil in decreasing hair growth
    GHADA FAROUK ABD EL-KAREAM
    J Intercult Ethnopharmacol. 2012; 1(2): 111-118
    » Abstract & References » doi: 10.5455/jice.20120626100304

  • Ethno-dentistry: popular medicinal plants used for dental diseases in India
    Amit Bhardwaj, Shalu Verma Bhardwaj
    J Intercult Ethnopharmacol. 2012; 1(1): 62-65
    » Abstract & References » doi: 10.5455/jice.20120322035152

  • Studies with Myrtus communis L.: Anticancer Properties
    Recai Ogur
    J Intercult Ethnopharmacol. 2014; 3(4): 135-137
    » Abstract & References » doi: 10.5455/jice.20140803044831

  • Total phenolic, flavonoids and tannin contents in different extracts of Artemisia absinthium
    Rajeev Singh, Pawan Kumar Verma, Gagandeep Singh
    J Intercult Ethnopharmacol. 2012; 1(2): 101-104
    » Abstract & References » doi: 10.5455/jice.20120525014326

  • Antimicrobial and phytochemical evaluation of the leaf, stem bark and root extracts of Cyathula prostrata (L) Blume against some human pathogens
    Gideon Ikechukwu Ogu, Williams Omotola Tanimowo, Perpetua Ugonna Nwachukwu, Bright Esegbuyota Igere
    J Intercult Ethnopharmacol. 2012; 1(1): 35-43
    » Abstract & References » doi: 10.5455/jice.20120407085952

  • Herbal Antibacterials: A Review
    Chirag Modi, Shailesh Mody, Hitesh Patel, Ghanshyam Dudhatra, Avinash Kumar, Madhavi Awale
    J Intercult Ethnopharmacol. 2012; 1(1): 52-61
    » Abstract & References » doi: 10.5455/jice.20120207113423

  • Preliminary phytochemical screening and evaluation of antibacterial activity of Dichrocepala integrifolia (L.f) O. kuntze
    Tesfaye Mohammed, Chalachew Teshale
    J Intercult Ethnopharmacol. 2012; 1(1): 30-34
    » Abstract & References » doi: 10.5455/jice.20120401054654

  • Medicinal plants with potential anti-arthritic activity:
    Manjusha Choudhary, Vipin Kumar, Hitesh Malhotra, Surender Singh
    J Intercult Ethnopharmacol. 2015; 4(2): 147-179
    » Abstract & References » doi: 10.5455/jice.20150313021918

  • Phytochemical and antibacterial activity of the extracts of Fagara zanthoxyloides on selected cariogenic and enteric bacterial isolates
    Martins Ajibade Adefisoye, Kwashie AjibadeAko-Nai, Mary Adejumoke Bisi-Johnson
    J Intercult Ethnopharmacol. 2012; 1(1): 1-6
    » Abstract & References » doi: 10.5455/jice.55-1333123486

  • Effect of Momordica charantia (bitter melon) on serum glucose level and various protein parameters in acetaminophen intoxicated rabbits
    Kanwal Zahra, Muhammad Imran Sohail, Muhammad Anwar Malik
    J Intercult Ethnopharmacol. 2012; 1(1): 7-12
    » Abstract & References » doi: 10.5455/jice.20120403013109

  • Most Downloaded
  • Studies with Myrtus communis L.: Anticancer Properties
    Recai Ogur
    J Intercult Ethnopharmacol. 2014; 3(4): 135-137
    » Abstract & References » doi: 10.5455/jice.20140803044831

  • Total phenolic, flavonoids and tannin contents in different extracts of Artemisia absinthium
    Rajeev Singh, Pawan Kumar Verma, Gagandeep Singh
    J Intercult Ethnopharmacol. 2012; 1(2): 101-104
    » Abstract & References » doi: 10.5455/jice.20120525014326

  • Herbal Antibacterials: A Review
    Chirag Modi, Shailesh Mody, Hitesh Patel, Ghanshyam Dudhatra, Avinash Kumar, Madhavi Awale
    J Intercult Ethnopharmacol. 2012; 1(1): 52-61
    » Abstract & References » doi: 10.5455/jice.20120207113423

  • Ethno-dentistry: popular medicinal plants used for dental diseases in India
    Amit Bhardwaj, Shalu Verma Bhardwaj
    J Intercult Ethnopharmacol. 2012; 1(1): 62-65
    » Abstract & References » doi: 10.5455/jice.20120322035152

  • Antimicrobial and phytochemical evaluation of the leaf, stem bark and root extracts of Cyathula prostrata (L) Blume against some human pathogens
    Gideon Ikechukwu Ogu, Williams Omotola Tanimowo, Perpetua Ugonna Nwachukwu, Bright Esegbuyota Igere
    J Intercult Ethnopharmacol. 2012; 1(1): 35-43
    » Abstract & References » doi: 10.5455/jice.20120407085952

  • Role of Cyperus rotundus oil in decreasing hair growth
    GHADA FAROUK ABD EL-KAREAM
    J Intercult Ethnopharmacol. 2012; 1(2): 111-118
    » Abstract & References » doi: 10.5455/jice.20120626100304

  • A review on ethnopharmacological potential of Aloe vera L.
    Md. Shamim Hossain, A.N.M Mamun-Or-Rashid, Nayeem Md. Towfique, Monokesh Kumer Sen
    J Intercult Ethnopharmacol. 2013; 2(2): 113-120
    » Abstract & References » doi: 10.5455/jice.20130612035300

  • Preliminary phytochemical screening and evaluation of antibacterial activity of Dichrocepala integrifolia (L.f) O. kuntze
    Tesfaye Mohammed, Chalachew Teshale
    J Intercult Ethnopharmacol. 2012; 1(1): 30-34
    » Abstract & References » doi: 10.5455/jice.20120401054654

  • Phytochemical and antibacterial activity of the extracts of Fagara zanthoxyloides on selected cariogenic and enteric bacterial isolates
    Martins Ajibade Adefisoye, Kwashie AjibadeAko-Nai, Mary Adejumoke Bisi-Johnson
    J Intercult Ethnopharmacol. 2012; 1(1): 1-6
    » Abstract & References » doi: 10.5455/jice.55-1333123486

  • Use of Aqueous Extract of Corn Silk in the Treatment of Urinary Tract Infection
    Ahmed Salih Sahib, Imad Hashim Mohammed, Saba Jasim Hamdan
    J Intercult Ethnopharmacol. 2012; 1(2): 93-96
    » Abstract & References » doi: 10.5455/jice.20120525123150

  • Most Cited Articles
  • Total phenolic, flavonoids and tannin contents in different extracts of Artemisia absinthium
    Rajeev Singh, Pawan Kumar Verma, Gagandeep Singh
    J Intercult Ethnopharmacol. 2012; 1(2): 101-104
    » Abstract & References » doi: 10.5455/jice.20120525014326
    Cited : 27 times [Click to see citing articles]

  • Antimicrobial and phytochemical evaluation of the leaf, stem bark and root extracts of Cyathula prostrata (L) Blume against some human pathogens
    Gideon Ikechukwu Ogu, Williams Omotola Tanimowo, Perpetua Ugonna Nwachukwu, Bright Esegbuyota Igere
    J Intercult Ethnopharmacol. 2012; 1(1): 35-43
    » Abstract & References » doi: 10.5455/jice.20120407085952
    Cited : 11 times [Click to see citing articles]

  • Some pharmacological effects of cinnamon and ginger herbs in obese diabetic rats
    Mostafa Abbas Shalaby, Hamed Yahya Saifan
    J Intercult Ethnopharmacol. 2014; 3(4): 144-149
    » Abstract & References » doi: 10.5455/jice.20140818050741
    Cited : 9 times [Click to see citing articles]

  • Analgesic, Anti-inflammatory and Antihyperlipidemic Activities of Commiphora molmol Extract (Myrrh)
    Mostafa Abbas Shalaby, Ashraf Abd-Elkhalik Hammouda
    J Intercult Ethnopharmacol. 2014; 3(2): 56-62
    » Abstract & References » doi: 10.5455/jice.20140130015014
    Cited : 8 times [Click to see citing articles]

  • Guava leaves polyphenolics-rich extract inhibits vital enzymes implicated in gout and hypertension in vitro
    Emmanuel Anyachukwu Irondi, Samson Olalekan Agboola, Ganiyu Oboh, Aline Augusti Boligon, Margareth Linde Athayde, Francis O. Shode
    J Intercult Ethnopharmacol. 2016; 5(2): 122-130
    » Abstract & References » doi: 10.5455/jice.20160321115402
    Cited : 8 times [Click to see citing articles]

  • Potential antimalarials from African natural products: a review
    Bashir Lawal, Oluwatosin Kudirat Shittu, Adamu Yusuf Kabiru, Ali Audu Jigam, Maimuna Bello Umar, Eustace Bonghan Berinyuy, Blessing Uchenna Alozieuwa
    J Intercult Ethnopharmacol. 2015; 4(4): 318-343
    » Abstract & References » doi: 10.5455/jice.20150928102856
    Cited : 6 times [Click to see citing articles]

  • Study of antinociceptive and anti-inflammatory activities of certain Iranian medicinal plants
    Fariba Sharififar, Payam Khazaeli, Narguess Alli, Elham Talebian, Raheleh Zarehshahi, Shivasadat Amiri
    J Intercult Ethnopharmacol. 2012; 1(1): 19-24
    » Abstract & References » doi: 10.5455/jice.20120227104636
    Cited : 5 times [Click to see citing articles]

  • Preliminary phytochemical screening and evaluation of antibacterial activity of Dichrocepala integrifolia (L.f) O. kuntze
    Tesfaye Mohammed, Chalachew Teshale
    J Intercult Ethnopharmacol. 2012; 1(1): 30-34
    » Abstract & References » doi: 10.5455/jice.20120401054654
    Cited : 5 times [Click to see citing articles]

  • Herbal medicine use among Turkish patients with chronic diseases
    Mnevver Tulunay, Cenk Aypak, Hlya Yklkan, Sleyman Grpeliolu
    J Intercult Ethnopharmacol. 2015; 4(3): 217-220
    » Abstract & References » doi: 10.5455/jice.20150623090040
    Cited : 5 times [Click to see citing articles]

  • α-Glucosidase and α -amylase inhibitory activities of Mukia maderaspatana (L) Roem
    Vadivelan Ramachandran
    J Intercult Ethnopharmacol. 2012; 1(2): 97-100
    » Abstract & References » doi: 10.5455/jice.20120616023239
    Cited : 4 times [Click to see citing articles]