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Biomedical properties and potentiality of Lippia microphylla Cham. and its essential oils

Evelyne Rolim Braun Simões, Evelyne Alves Santos, Maria Carolina de Abreu, Jurandy do Nascimento Silva, Nárcia Mariana Fonseca Nunes, Marcília Pinheiro da Costa, Otília Deusdênia Loiola Pessoa, Cláudia Pessoa, Paulo Michel Pinheiro Ferreira.

Cited by (5)

Abstract
Lippia microphylla Cham. (Verbanaceae) is an endemic underexploited Brazilian vegetal. This work reviewed the biological potentialities of Lippia microphylla, emphasizing the properties of essential oils (EOs) and analyzed scientific indicators about genus Lippia and L. microphylla. Databases from 1948 to the present were searched and a software (Vantage Point 7.1) associated with Derwent Innovation Index was used to identify the indicators of the genus Lippia, and biological activities and compounds in the L. macrophylla species. Ethnopharmacological records report use of L. microphylla leaves to treat gastrointestinal disorders, influenza, bronchitis, cough, nasal congestion and sinusitis during vaporization, whose aromatic volatile oils are rich in monoterpenes, especially cineole, terpineol and thymol. Other EOs have larvicidal activity on Aedes aegypti larvae, and antifungal, antibacterial and cytotoxic and antitumor action on human and murine cancer cells. Brazil is the country with more articles about Lippia species, but it deposited only 9 patents since 1993. Most of the publications about L. microphylla are concentrated in food and chemical sciences. This bioprospection helps to choice areas of interest for capital investment and to give support for Brazilian Institutions to establish cooperation and improve technological impact at the point of view of creation and innovation.

Key words: Lippia microphylla, pharmacological activity, antitumor action, terpenes, scientific indicators.


 
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REFERENCES
1. World Health Organization. The World medicines situation 2011. Traditional medicines: Global situation, issues and challenges. Geneva: WHO; 2011. p. 1-14.
2. Butler MS. The role of natural product chemistry in drug discovery. J Nat Prod 2004;67:2141-53. [DOI via Crossref]    [Pubmed]   
3. Ferreira PM, Farias DF, Viana MP, Souza TM, Vasconcelos IM, Soares BM, et al. Study of the antiproliferative potential of seed extracts from Northeastern Brazilian plants. An Acad Bras Cienc 2011;83:1045-58. [DOI via Crossref]    [Pubmed]   
4. Araújo EJF, Araújo DYML, Freitas RM, Ferreira PMP. Toxicology of the medicinal plant Casearia sylvestris Swartz: A literature review. Rev Cienc Farm Basica Apl 2014;35:355-61.
5. Militão GC, Dantas IN, Ferreira PM, Alves AP, Chaves DC, Monte FJ, et al. In vitro and in vivo anticancer properties of cucurbitacin isolated from Cayaponia racemosa. Pharm Biol 2012;50:1479-87. [DOI via Crossref]    [Pubmed]   
6. Carvalho CC, Micheletti AC, Ferreira PM, Pessoa C, Fonseca TH, Gomes MA, et al. Biological screening of extracts of Brazilian Asteraceae plants. Afr J Pharm Pharmacol 2013;7:2000-5. [DOI via Crossref]   
7. Terblanché FC, Kornelius G. Essential oil constituents of the genus Lippia (Verbenaceae) – A literature review. J Essent Oil Res 1996;8:471-85. [DOI via Crossref]   
8. Santos JS, Melo JIM, Abreu MC, Sales MF. Verbenaceae sensu stricto in the region of Xingó: Alagoas e Sergipe, Brazil. Rodriguésia 2009;40:985-98.
9. Agra MF, Baracho GS, Nurit K, Basílio IJ, Coelho VP. Medicinal and poisonous diversity of the flora of "Cariri Paraibano", Brazil. J Ethnopharmacol 2007;111:383-95. [DOI via Crossref]    [Pubmed]   
10. Santos JP, Araújo EL, Albuquerque UP. Richness and distribution of useful woody plants in the semi-arid region of Northeastern Brazil. J Arid Environ 2008;72:652-63. [DOI via Crossref]   
11. Lorenzi H, Matos FJA. Medicinal Plants in Brazil: Natives e Exotics. Nova Odessa; 2002. p. 1-512.
12. Pham Huu Chanh, Koffi Y, Pham Huu Chanh A. Comparative hypotensive effects of compounds extracted from Lippia multiflora leaves. Planta Med 1988;54:294-6. [DOI via Crossref]   
13. Souto-Bachiller FA, Jesus-Echevarria M, Cárdenas-Gonzalez OE, Acu-a-Rodriguez MF, Meléndedez RA, Romero-Ramsey L. Terpenoid composition of Lippia dulcis. Phytochemistry 1997;44:1077-86. [DOI via Crossref]   
14. Pascual ME, Slowing K, Carretero E, Sánchez Mata D, Villar A. Lippia: Traditional uses, chemistry and pharmacology: A review. J Ethnopharmacol 2001;76:201-14. [DOI via Crossref]   
15. Matos FJA, Oliveira F. Lippia sidoides Cham. Pharmacognosy, chemistry and pharmacology. Rev Bras Farmacogn 1998;79:84-7.
16. Abad MJ, Bermejo P, Villar A, Palomino SS, Carraso L. Antiviral activity of medicinal plant extracts. Phytother Res 1997;11:198-202. [DOI via Crossref]   
17. Valentin A, Pélissier Y, Benoit F, Marion C, Kone D, Mallie M, et al. Composition and antimalarial activity in vitro of volatile components of Lippia multiflora. Phytochemistry 1995;40:1439-42. [DOI via Crossref]   
18. Forestieri AM, Monforte MT, Ragusa S, Trovato A. Antiinflammatory, analgesic and antipyretic activity in rodents of plant extracts used in African medicine. Phytother Re 1996;10:100-6. [DOI via Crossref]   
19. Lemos TL, Matos FJ, Alencar JW, Craveiro AA. Antimicrobial activity of essential oils of Brazilian plants. Phytother Res 1990;4:82-4. [DOI via Crossref]   
20. Souza EL, Lima EO, Freire KR, Sousa CP. Inhibitory action of some essential oils and phytochemicals on the growth of various moulds isolated from foods. Braz Arch Biol Technol 2005;48:245-50. [DOI via Crossref]   
21. Botelho MA, Nogueira NAP, Bastos GM, Fonseca SGC, Lemos TLG, Matos FJA, et al. The antimicrobial The antimicrobial activity of essential oil of Lippia sidoides, carvacrol and thymol against oral pathogens. Braz J Med 2007;40:349-56. [DOI via Crossref]   
22. Oliveira DR, Leitao GG, Bizzo HR, Lopes D, Alviano DS, Leitão SG. (2007). Chemical and antimicrobial analyses of the essential oil of Lippia origanoides H.B.K. Food Chem 2007;101:236-40. [DOI via Crossref]   
23. Silva VA, Freitas AFR, Pereira MSV, Siqueira Júnior JP, Pereira AV, Higino JS. In vitro evaluation of the antimicrobial activity of Lippia sidoides Cham extract. on biological isolates of Staphylococcus aureus. Rev Bras Plantas Med 2010;12:452-5.
24. Funari CS, Gullo FP, Napolitano A, Carneiro RL, Mendes-Giannini MJ, Fusco-Almeida AM, et al. Chemical and antifungal investigations of six Lippia species (Verbenaceae) from Brazil. Food Chem 2012;135:2086-94. [DOI via Crossref]    [Pubmed]   
25. Veras HN, Rodrigues FF, Colares AV, Menezes IR, Coutinho HD, Botelho MA, et al. Synergistic antibiotic activity of volatile compounds from the essential oil of Lippia sidoides and thymol. Fitoterapia 2012;83:508-12. [DOI via Crossref]    [Pubmed]   
26. de Lima GP, de Souza TM, de Paula Freire G, Farias DF, Cunha AP, Ricardo NM, et al. Further insecticidal activities of essential oils from Lippia sidoides and Croton species against Aedes aegypti L. Parasitol Res 2013;112:1953-8. [DOI via Crossref]    [Pubmed]   
27. Abena AA, Ngondzo-Kombeti GR, Bioka D. Psychopharmacologic properties of Lippia multiflora. Encephale 1998;24:449-54. [Pubmed]   
28. Costa SM, Lemos TL, Pessoa OD, Pessoa C, Montenegro RC, BrazFilho R. Chemical constituents from Lippia sidoides and cytotoxic activity. J Nat Prod 2001;64:792-5. [DOI via Crossref]    [Pubmed]   
29. Mesa-Arango AC, Montiel-Ramos J, Zapata B, Durán C, BetancurGalvis L, Stashenko E. Citral and carvone chemotypes from the essential oils of Colombian Lippia alba (Mill.) N.E. Brown: Composition, cytotoxicity and antifungal activity. Mem Inst Oswaldo Cruz 2009;104:878-84. [DOI via Crossref]    [Pubmed]   
30. Gonzalez-Guëreca MC, Soto-Hernandez M, Martinez-Vazquez M. Isolation of (-)(2S)-5,6,7,3',5'-pentahydroxyflavanone-7-O-ß-Dglucopyranoside, from Lippia graveolens H.B.K. var. berlandieri Schauer, a new anti-inflammatory and cytotoxic flavanone. Nat Prod Res 2010;24:1528-36. [DOI via Crossref]    [Pubmed]   
31. Compadre CM, Robbins EF, Kinghorn AD. The intensely sweet herb, Lippia dulcis Trev: Historical uses, field inquiries, and constituents. J Ethnopharmacol 1986;15:89-106. [DOI via Crossref]   
32. Kaneda N, Lee IS, Gupta MP, Soejarto DD, Kinghorn AD. (+) v-4 betahydroxyhernandulcin, a new sweet sesquiterpene from the leaves and flowers of Lippia dulcis. J Nat Prod 1992;55:1136-41. [DOI via Crossref]    [Pubmed]   
33. Santos HS, Silveira ER, Costa SM, Lemos TL, Pessoa OD, Uchoa DE. 1H and 13C NMR application to structure elucidations of prenylated naphthoquinone dimers from Lippia microphylla. An Ressonância Magn Nucl 2002;1:32-6.
34. Santos HS, Costa SM, Pessoa OD, Moraes MO, Pessoa C, Fortier S, et al. Cytotoxic naphthoquinones from roots of Lippia microphylla. Z Naturforsch C 2003;58:517-20. [DOI via Crossref]    [Pubmed]   
35. López-Alarcón C, Denicola A. Evaluating the antioxidant capacity of natural products: A review on chemical and cellular-based assays. Anal Chim Acta 2013;763:1-10. [DOI via Crossref]    [Pubmed]   
36. Farias DF, Souza TM, Viana MP, Soares BM, Cunha AP, Vasconcelos IM, et al. Antibacterial, antioxidant, and anticholinesterase activities of plant seed extracts from Brazilian semiarid region. Biomed Res Int 2013;2013:510736. [DOI via Crossref]    [Pubmed]    [PMC Free Fulltext]   
37. Carvalho AF, Melo VM, Craveiro AA, Machado MI, Bantim MB, Rabelo EF. Larvicidal activity of the essential oil from Lippia sidoides Cham. Against Aedes aegypti linn. Mem Inst Oswaldo Cruz 2003;98:569-71. [DOI via Crossref]    [Pubmed]   
38. Cavalcanti ES, Morais SM, Lima MA, Santana EW. Larvicidal activity of essential oils from Brazilian plants against Aedes aegypti L. Mem Inst Oswaldo Cruz 2004;99:541-4. [DOI via Crossref]    [Pubmed]   
39. Santiago GM, Lemos TL, Pessoa OD, Arriaga AM, Matos FJ, Lima MA, et al. Larvicidal activity against Aedes aegypti L. (Diptera: Culicidae) essential oils of Lippia species from Brazil. Nat Prod Commun 2006;1:573-6.
40. Folashade KO, Omoregie EH. Essential oil of Lippia multiflora Moldenke: A review. J App Pharm Sci 2012;2:15-23.
41. Gleiser RM, Bonino MA, Zygadlo JA. Repellence of essential oils of aromatic plants growing in Argentina against Aedes aegypti (Diptera: Culicidae). Parasitol Res 2011;108:69-78. [DOI via Crossref]    [Pubmed]   
42. Environmental Protection Agency (EPA). Reregistration Eligibility Decision (RED) facts: Limonene. EPA-738-F-94-030. Washington: EPA 1994. p. 1-5.
43. Hebeish A, Fouda MM, Hamdy IA, El-Sawy SM, Abdel-Mohdy FA. Preparation of durable insect repellent cotton fabric: Limonene as insecticide. Carbohydr Polym 2008;74:268-73. [DOI via Crossref]   
44. Costa SM, Santos HS, Lemos TL, Pessoa OD. Constituents of the essential oil of Lippia microphylla Cham. from Northeast of Brazil. J Essent Oil Res 2005;17:378-9. [DOI via Crossref]   
45. Rodrigues FF, Henrique DM, Campos AR, Sidney GL, Costa JG. Antibacterial activity and chemical composition of essential oil of Lippia microphylla Cham. Acta Sci Bio Sci 2011;33:141-4.
46. Schurt DA, Trassato LB, Souza GR, Silva WL. Use of essential oil of Lippia microphylla on in vitro growth inhibition of Rhizoctonia solani. Trop Plant Pathol 2012;38:34-9.
47. Cowan MM. Plant products as antimicrobial agents. Clin Microbiol Rev 1999;12:564-82. [Pubmed]    [PMC Free Fulltext]   
48. Lakusici B, Ristic M, Slavkovski V, Stankovic JA, Milenkovic M. Chemical composition and antimicrobial of the essential oil from Satureja horvatii Silic (Lamiaceae). J Serb Chem Soc 2008;73:703-11. [DOI via Crossref]   
49. David JP, Meira M, David JM, Brandão HN, Branco A, de Fátima Agra M, et al. Radical scavenging, antioxidant and cytotoxic activity of Brazilian Caatinga plants. Fitoterapia 2007;78:215-8. [DOI via Crossref]    [Pubmed]   
50. Silva PS, Viccini LF, Singulani JL, Siqueira EP, Zani CL, Alves TM. Chemical composition of the essential oil and hexanic fraction of Lippia and Lantana species. Rev Bras Farmacognosia 2010;20:843-9. [DOI via Crossref]   
51. Mosmann T. Rapid colorimetric assay for cellular growth and survival: Application to proliferation and cytotoxicity assays. J Immunol Methods 1983;65:55-63. [DOI via Crossref]   
52. Xavier AL. Study of the potential antitumor the essential oil of Lippia microphylla leaves call (Verbenaceae) and its toxicity. Post-graduate Program in Natural Products and Synthetic Bioactives. João Pessoa: UFPB; 2011. p. 1-95.
53. Wu YJ, Muldoon LL, Neuwelt EA. The chemoprotective agent N-acetylcysteine blocks cisplatin-induced apoptosis through caspase signaling pathway. J Pharmacol Exp Ther 2005;312:424-31. [DOI via Crossref]    [Pubmed]   
54. Hengartner MO. The biochemistry of apoptosis. Nature 2000;407:770-6. [DOI via Crossref]    [Pubmed]   
55. Hanahan D, Weinberg RA. Hallmarks of cancer: The next generation. Cell 2011;144:646-74. [DOI via Crossref]    [Pubmed]   
56. Cao DX, Qiao B, Ge ZQ, Yuan YJ. Comparison of burst of reactive oxygen species and activation of caspase-3 in apoptosis of K562 and HL-60 cells induced by docetaxel. Cancer Lett 2004;214:103-13. [DOI via Crossref]    [Pubmed]   
57. Meshkini A, Yazdanparast R. Involvement of oxidative stress in taxolinduced apoptosis in chronic myelogenous leukemia K562 cells. Exp Toxicol Pathol 2012;64:357-65. [DOI via Crossref]    [Pubmed]   
58. Santos MDM, Coelho GM, Santos DMD, Filho LF. Prospecting of Future Technologies: Methods, Techniques and Approaches. Brasília: CGEE; 2004. p. 198-229. [Pubmed]   
59. Marques LG, Simões ER, Ferreira PM, Santos MR, Pessoa C. Development of the technological potential of Casearia sylvestris. Rev Geintec 2013;3:70-85. [DOI via Crossref]   
60. Zackiewicz M, Salles-Filho S. Technological foresight: A tool for science and technology policy. Parcerias Estratégicas 2001;10:144-61.
61. Brasil. Ministry of Health. Secretariat of Science, Technology and Strategic Inputs. Department of Pharmaceutical Services. National Policy of Medicinal Plants and Herbal Medicines. Brasília: Série B - Textos Básicos de Saúde; 2006. p. 1-60.
62. Brasil. Presidency, Civil House, deputy chef for Legal Affairs. Law No 10,973/2004. http://www.planalto.gov.br /ccivil03/ato2004- 2006/2004/lei/l10.973.htm>. [Access date 21.02.2015.
63. Speziali MG, Guimarães PPG, Sinisterra RD. Demystifying patent protection in universities. Quim Nova 2012;35:1700-5. [DOI via Crossref]   
64. Klein T, Longhini R, Bruschi ML, Mello JCP. Herbal Medicines: A Promising Market. Rev Ciênc Farm Básica Apl 2009;30:241-8.
65. Institute for Healthcare Informatics. 2011. The Global use of medicines: Outlook trough 2015. Available from: http://www.imshealth. com/deployedfiles/ims//Insights/IMS%20Institute20for%20 Healthcare%20Informatics/Global_Use_of_Medicines_Report.pdf. [Last accessed on 2014 Jul 07].

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How to Cite this Article
Pubmed Style

Simões ERB, Santos EA, Abreu MCd, Silva JdN, Nunes NMF, Costa MPd, Pessoa ODL, Pessoa C, Ferreira PMP. Biomedical properties and potentiality of Lippia microphylla Cham. and its essential oils. J Intercult Ethnopharmacol. 2015; 4(3): 256-263. doi:10.5455/jice.20150610104841


Web Style

Simões ERB, Santos EA, Abreu MCd, Silva JdN, Nunes NMF, Costa MPd, Pessoa ODL, Pessoa C, Ferreira PMP. Biomedical properties and potentiality of Lippia microphylla Cham. and its essential oils. http://www.jicep.com/?mno=181021 [Access: December 15, 2017]. doi:10.5455/jice.20150610104841


AMA (American Medical Association) Style

Simões ERB, Santos EA, Abreu MCd, Silva JdN, Nunes NMF, Costa MPd, Pessoa ODL, Pessoa C, Ferreira PMP. Biomedical properties and potentiality of Lippia microphylla Cham. and its essential oils. J Intercult Ethnopharmacol. 2015; 4(3): 256-263. doi:10.5455/jice.20150610104841



Vancouver/ICMJE Style

Simões ERB, Santos EA, Abreu MCd, Silva JdN, Nunes NMF, Costa MPd, Pessoa ODL, Pessoa C, Ferreira PMP. Biomedical properties and potentiality of Lippia microphylla Cham. and its essential oils. J Intercult Ethnopharmacol. (2015), [cited December 15, 2017]; 4(3): 256-263. doi:10.5455/jice.20150610104841



Harvard Style

Simões, E. R. B., Santos, E. A., Abreu, M. C. d., Silva, J. d. N., Nunes, N. M. F., Costa, M. P. d., Pessoa, O. D. L., Pessoa, C. & Ferreira, P. M. P. (2015) Biomedical properties and potentiality of Lippia microphylla Cham. and its essential oils. J Intercult Ethnopharmacol, 4 (3), 256-263. doi:10.5455/jice.20150610104841



Turabian Style

Simões, Evelyne Rolim Braun, Evelyne Alves Santos, Maria Carolina de Abreu, Jurandy do Nascimento Silva, Nárcia Mariana Fonseca Nunes, Marcília Pinheiro da Costa, Otília Deusdênia Loiola Pessoa, Cláudia Pessoa, and Paulo Michel Pinheiro Ferreira. 2015. Biomedical properties and potentiality of Lippia microphylla Cham. and its essential oils. Journal of Intercultural Ethnopharmacology, 4 (3), 256-263. doi:10.5455/jice.20150610104841



Chicago Style

Simões, Evelyne Rolim Braun, Evelyne Alves Santos, Maria Carolina de Abreu, Jurandy do Nascimento Silva, Nárcia Mariana Fonseca Nunes, Marcília Pinheiro da Costa, Otília Deusdênia Loiola Pessoa, Cláudia Pessoa, and Paulo Michel Pinheiro Ferreira. "Biomedical properties and potentiality of Lippia microphylla Cham. and its essential oils." Journal of Intercultural Ethnopharmacology 4 (2015), 256-263. doi:10.5455/jice.20150610104841



MLA (The Modern Language Association) Style

Simões, Evelyne Rolim Braun, Evelyne Alves Santos, Maria Carolina de Abreu, Jurandy do Nascimento Silva, Nárcia Mariana Fonseca Nunes, Marcília Pinheiro da Costa, Otília Deusdênia Loiola Pessoa, Cláudia Pessoa, and Paulo Michel Pinheiro Ferreira. "Biomedical properties and potentiality of Lippia microphylla Cham. and its essential oils." Journal of Intercultural Ethnopharmacology 4.3 (2015), 256-263. Print. doi:10.5455/jice.20150610104841



APA (American Psychological Association) Style

Simões, E. R. B., Santos, E. A., Abreu, M. C. d., Silva, J. d. N., Nunes, N. M. F., Costa, M. P. d., Pessoa, O. D. L., Pessoa, C. & Ferreira, P. M. P. (2015) Biomedical properties and potentiality of Lippia microphylla Cham. and its essential oils. Journal of Intercultural Ethnopharmacology, 4 (3), 256-263. doi:10.5455/jice.20150610104841





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