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Original Research Open Access


The subtle central effect of nutraceuticals: Is it placebo or nocebo?

Ali I. Al-Gareeb.

Abstract
Background: Herbal medicines are often perceived by the general public as a “soft” alternative to Western Medicine, but the use of these substances can be risky since they can induce nocebo effect
Aim: To evaluate the nocebo effects of nigella sativa oil, garlic and CoQ10 on the integrative function of central nervous system and psychomotor performance
Subjects and methods: This is a randomized, double-blind, controlled, and prospective study conducted in the Department of Pharmacology, College of Medicine, Al-Mustansiriya University, Baghdad, Iraq during February 2013. One hundred sixty medical students participated in the study were randomly assigned equally to one of the following groups: Group A: received single dose of nigella sativa oil (500 ml capsule);Group B: received single dose of garlic (500 mg capsule); Group C: received single dose of Coq10 (120 mg capsule) and; Group D: received single dose of matching oral placebo (300mg starchc capsule). For all participants, reaction time and flicker fusion threshold were measured by the Leeds psychomotor performance test battery before and after 3 hours of taking the drugs
Results: Neither placebo nor nutraceuticals exerted significant effect on total reaction time. Although the recognition reaction time is insignificantly reduced by 2.77% (placebo), 5.83% (Nigella savita), 7.21% (Garlic) and 12.64% (CoQ10) from the pretreatment values, they are adversely affect the motor reaction time to reach the significant level in subjects pretreated with Garlic (p=0.02).
Conclusion: Nutraceuticals are not free from nocebo effect on psychomotor performance.

Key words: psychomotor performance, nigella sativa oil, garlic and CoQ10


 
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How to Cite this Article
Pubmed Style

Ali I. Al-Gareeb. The subtle central effect of nutraceuticals: Is it placebo or nocebo?. J Intercult Ethnopharmacol. 2015; 4(3): 221-223. doi:10.5455/jice.20150403055054



Web Style

Ali I. Al-Gareeb. The subtle central effect of nutraceuticals: Is it placebo or nocebo?. www.scopemed.org/?mno=182949 [Access: November 18, 2017]. doi:10.5455/jice.20150403055054



AMA (American Medical Association) Style

Ali I. Al-Gareeb. The subtle central effect of nutraceuticals: Is it placebo or nocebo?. J Intercult Ethnopharmacol. 2015; 4(3): 221-223. doi:10.5455/jice.20150403055054



Vancouver/ICMJE Style

Ali I. Al-Gareeb. The subtle central effect of nutraceuticals: Is it placebo or nocebo?. J Intercult Ethnopharmacol. (2015), [cited November 18, 2017]; 4(3): 221-223. doi:10.5455/jice.20150403055054



Harvard Style

Ali I. Al-Gareeb (2015) The subtle central effect of nutraceuticals: Is it placebo or nocebo?. J Intercult Ethnopharmacol, 4 (3), 221-223. doi:10.5455/jice.20150403055054



Turabian Style

Ali I. Al-Gareeb. 2015. The subtle central effect of nutraceuticals: Is it placebo or nocebo?. Journal of Intercultural Ethnopharmacology, 4 (3), 221-223. doi:10.5455/jice.20150403055054



Chicago Style

Ali I. Al-Gareeb. "The subtle central effect of nutraceuticals: Is it placebo or nocebo?." Journal of Intercultural Ethnopharmacology 4 (2015), 221-223. doi:10.5455/jice.20150403055054



MLA (The Modern Language Association) Style

Ali I. Al-Gareeb. "The subtle central effect of nutraceuticals: Is it placebo or nocebo?." Journal of Intercultural Ethnopharmacology 4.3 (2015), 221-223. Print. doi:10.5455/jice.20150403055054



APA (American Psychological Association) Style

Ali I. Al-Gareeb (2015) The subtle central effect of nutraceuticals: Is it placebo or nocebo?. Journal of Intercultural Ethnopharmacology, 4 (3), 221-223. doi:10.5455/jice.20150403055054





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