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Efficacy and Phytochemical Analysis of Aqueous Extract of Calotropis procera against Selected Dermatophytes

Rabiu Muhammad Aliyu, Mikaeel Bala Abubakar, Adamu Bello Kasarawa, Yakubu Umar Dabai, Nafiu Lawal, Muhammad Bashir Bello, Aminu Yusuf Fardami.

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Abstract
Since ancient time, an increased interest had been witnessed in the use of an alternative herbal medicine for managing and the treatment of fungal disease worldwide. This may be connected to the cost and relative toxicities of the available fungal drugs. Since ancient time, it has been a known tradition practised in the northern part of Nigeria that parents and teachers use the white latex of Calotropis procera (Tumfafiya) to treat Tinea capitis (Makero) in children attending the local religious school in the area. This study was conducted in 2009 to designed to ascertain the above claim scientifically. Latex extract of Calotropis procera was screened for their antifungal and phytochemical properties. Agar incorporation method against species of dermatophytes: Trichophyton sp., Microsporum sp. and Epidermophyton sp. shows that the latex inhibits the in vitro growth of these three filamentous fungi to varying extents. Statistical analysis of the results shows that Trichophyton sp. is the most susceptible and thus highly inhabited by the latex extract followed by the Microsporum Sp. and Epidermopyton sp. was least inhibited. Undiluted latex (100%) of C. procera gave the highest inhibitory impacts on the dermatophytes and corresponding lowest least (20%) concentration. The phytochemical analysis of the latex extract indicates the presence alkaloids, saponin, tannins, steroids, flavonoids, anthraquinone and triterpenoids. The findings of this study confirmed the perceived usefulness of the latex in the treatment of Tinea capitis (ringworm) practiced in the society and therefore, its use in the treatment of dermatomycotic infection is encouraged.

Key words: Calotropis procera, Antifungal activity, Dermatophytes


 
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This Article Cited By the following articles

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1
 

How to Cite this Article
Pubmed Style

Aliyu RM, Abubakar MB, Kasarawa AB, Dabai YU, Lawal N, Bello MB, Fardami AY. Efficacy and Phytochemical Analysis of Aqueous Extract of Calotropis procera against Selected Dermatophytes. J Intercult Ethnopharmacol. 2015; 4(4): 314-317. doi:10.5455/jice.20151012012909



Web Style

Aliyu RM, Abubakar MB, Kasarawa AB, Dabai YU, Lawal N, Bello MB, Fardami AY. Efficacy and Phytochemical Analysis of Aqueous Extract of Calotropis procera against Selected Dermatophytes. www.scopemed.org/?mno=200118 [Access: November 18, 2017]. doi:10.5455/jice.20151012012909



AMA (American Medical Association) Style

Aliyu RM, Abubakar MB, Kasarawa AB, Dabai YU, Lawal N, Bello MB, Fardami AY. Efficacy and Phytochemical Analysis of Aqueous Extract of Calotropis procera against Selected Dermatophytes. J Intercult Ethnopharmacol. 2015; 4(4): 314-317. doi:10.5455/jice.20151012012909



Vancouver/ICMJE Style

Aliyu RM, Abubakar MB, Kasarawa AB, Dabai YU, Lawal N, Bello MB, Fardami AY. Efficacy and Phytochemical Analysis of Aqueous Extract of Calotropis procera against Selected Dermatophytes. J Intercult Ethnopharmacol. (2015), [cited November 18, 2017]; 4(4): 314-317. doi:10.5455/jice.20151012012909



Harvard Style

Aliyu, R. M., Abubakar, M. B., Kasarawa, A. B., Dabai, Y. U., Lawal, N., Bello, M. B. & Fardami, A. Y. (2015) Efficacy and Phytochemical Analysis of Aqueous Extract of Calotropis procera against Selected Dermatophytes. J Intercult Ethnopharmacol, 4 (4), 314-317. doi:10.5455/jice.20151012012909



Turabian Style

Aliyu, Rabiu Muhammad, Mikaeel Bala Abubakar, Adamu Bello Kasarawa, Yakubu Umar Dabai, Nafiu Lawal, Muhammad Bashir Bello, and Aminu Yusuf Fardami. 2015. Efficacy and Phytochemical Analysis of Aqueous Extract of Calotropis procera against Selected Dermatophytes. Journal of Intercultural Ethnopharmacology, 4 (4), 314-317. doi:10.5455/jice.20151012012909



Chicago Style

Aliyu, Rabiu Muhammad, Mikaeel Bala Abubakar, Adamu Bello Kasarawa, Yakubu Umar Dabai, Nafiu Lawal, Muhammad Bashir Bello, and Aminu Yusuf Fardami. "Efficacy and Phytochemical Analysis of Aqueous Extract of Calotropis procera against Selected Dermatophytes." Journal of Intercultural Ethnopharmacology 4 (2015), 314-317. doi:10.5455/jice.20151012012909



MLA (The Modern Language Association) Style

Aliyu, Rabiu Muhammad, Mikaeel Bala Abubakar, Adamu Bello Kasarawa, Yakubu Umar Dabai, Nafiu Lawal, Muhammad Bashir Bello, and Aminu Yusuf Fardami. "Efficacy and Phytochemical Analysis of Aqueous Extract of Calotropis procera against Selected Dermatophytes." Journal of Intercultural Ethnopharmacology 4.4 (2015), 314-317. Print. doi:10.5455/jice.20151012012909



APA (American Psychological Association) Style

Aliyu, R. M., Abubakar, M. B., Kasarawa, A. B., Dabai, Y. U., Lawal, N., Bello, M. B. & Fardami, A. Y. (2015) Efficacy and Phytochemical Analysis of Aqueous Extract of Calotropis procera against Selected Dermatophytes. Journal of Intercultural Ethnopharmacology, 4 (4), 314-317. doi:10.5455/jice.20151012012909





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