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Design and characterisation of matrix tablets of highly water soluble drug

Vijayalakshmi Prakya, Surender Earati, Aroon A, Balamurgan AJ, Roopa Rani B, Sirisha Botla.

Abstract
Tramadol HCL is a centrally acting opioid analgesic. Although the drug has a higher plasma half life, the steady state plasma concentration is not achieved with frequent dosing of q.i.d at 6 hour intervals. Therefore, the objective of the present work was to formulate a 100mg strength Tramadol matrix tablets to extend the drug release and thus decrease the dosing frequency and achieve steady state plasma concentration. Initially, preformulation studies were carried out to rule out any incompatibility between the drug and the chosen polymer(s) after exposing physical mixtures of the drug and the polymer(s) to 40°C/75% RH for three months. A suitable method was developed for drug estimation at 271nm by a UV double beam spectrophotometer. Next, various batches of tablets were designed using different polymers such as Ethylcellulose, Carnauba wax, HPMC-K100M, Carbopol-974P and Kollidon-SR. Direct compression technique was used except for the formulation containing carnauba wax for which melt granulation was done followed by compression. Formulations F-1 to F-15 contained single polymers in increasing concentrations in drug:polymer ratios of 1:1, 1:2 and 1:3 where it was observed that the drug release extended with increasing polymer concentrations. Carbopol-974P extended drug release better followed by HPMC-K100M and Carnauba wax compared to other polymers. A combination of these polymers was also used at various ratios to get formulations F-16 to F-20 and observed that the polymer combinations controlled drug release better. The type of fillers like lactose and microcrystalline cellulose had no effect on the physiochemical characters as well as on the drug release profiles. The in vitro release data from the best formulation fitted well in Higuchi as well as Peppas model, the ‘n’ value, which confirmed that the release mechanism shifted from initial dissolution to later extended diffusion in which both diffusion and erosion governed the drug release.

Key words: Tramadol HCL, Controlled Release Tablets, Direct Compression Method and Melt Granulation Technique.


 
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How to Cite this Article
Pubmed Style

Prakya V, Earati S, A A, AJ B, B RR, Botla S. Design and characterisation of matrix tablets of highly water soluble drug. J Intercult Ethnopharmacol. 2012; 1(2): 85-92. doi:10.5455/jice.20120623123603


Web Style

Prakya V, Earati S, A A, AJ B, B RR, Botla S. Design and characterisation of matrix tablets of highly water soluble drug. http://www.jicep.com/?mno=20585 [Access: January 23, 2018]. doi:10.5455/jice.20120623123603


AMA (American Medical Association) Style

Prakya V, Earati S, A A, AJ B, B RR, Botla S. Design and characterisation of matrix tablets of highly water soluble drug. J Intercult Ethnopharmacol. 2012; 1(2): 85-92. doi:10.5455/jice.20120623123603



Vancouver/ICMJE Style

Prakya V, Earati S, A A, AJ B, B RR, Botla S. Design and characterisation of matrix tablets of highly water soluble drug. J Intercult Ethnopharmacol. (2012), [cited January 23, 2018]; 1(2): 85-92. doi:10.5455/jice.20120623123603



Harvard Style

Prakya, V., Earati, S., A, A., AJ, B., B, R. R. & Botla, S. (2012) Design and characterisation of matrix tablets of highly water soluble drug. J Intercult Ethnopharmacol, 1 (2), 85-92. doi:10.5455/jice.20120623123603



Turabian Style

Prakya, Vijayalakshmi, Surender Earati, Aroon A, Balamurgan AJ, Roopa Rani B, and Sirisha Botla. 2012. Design and characterisation of matrix tablets of highly water soluble drug. Journal of Intercultural Ethnopharmacology, 1 (2), 85-92. doi:10.5455/jice.20120623123603



Chicago Style

Prakya, Vijayalakshmi, Surender Earati, Aroon A, Balamurgan AJ, Roopa Rani B, and Sirisha Botla. "Design and characterisation of matrix tablets of highly water soluble drug." Journal of Intercultural Ethnopharmacology 1 (2012), 85-92. doi:10.5455/jice.20120623123603



MLA (The Modern Language Association) Style

Prakya, Vijayalakshmi, Surender Earati, Aroon A, Balamurgan AJ, Roopa Rani B, and Sirisha Botla. "Design and characterisation of matrix tablets of highly water soluble drug." Journal of Intercultural Ethnopharmacology 1.2 (2012), 85-92. Print. doi:10.5455/jice.20120623123603



APA (American Psychological Association) Style

Prakya, V., Earati, S., A, A., AJ, B., B, R. R. & Botla, S. (2012) Design and characterisation of matrix tablets of highly water soluble drug. Journal of Intercultural Ethnopharmacology, 1 (2), 85-92. doi:10.5455/jice.20120623123603





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