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Effects of Trichilia monadelpha (Meliaceae) extracts on bone histomorphology in complete Freundís adjuvant-induced arthritis

INEMESIT OKON BEN, Eric Woode, George Asumeng Koffuor, Eric Boakye-Gyasi, Nicholas Akinwale Titiloye.

Abstract
Aim: To assess the effect of petroleum ether extract (PEE), ethyl acetate extract (EthE), and ethanol extract (EAE) of Trichilia monadelpha stem bark on bone histomorphology in arthritis. Methods: Percentage inhibition of edema and arthritic scores in complete Freundís adjuvant-induced (0.1 ml of 5 mgml-1 of heat killed Mycobacterium tuberculosis in paraffin oil injected sub-plantar into the right hind paw) arthritic Sprague-Dawley rats treated with PEE, EthE, or EAE (10, 30, and 100 mgkg-1), dexamethasone (0.3-3.0 mgkg-1) or methotrexate (0.1Ė1.0 mgkg-1) over a 28-day period were estimated. Rat paws were radiographed and scored. Body weights were taken and paw tissues harvested for histopathological studies. Results: The extracts significantly (P‚ȧ0.01-0.0001) and dose-dependently reduced the polyarthritic phase of arthritis. EAE and PEE significantly (P‚ȧ0.01-0.0001) minimized edema spread from acute arthritic phase (day 0-10) to polyarthritic phase (day 10-28). EthE improved deteriorated body weight in arthritis. All extracts significantly (P‚ȧ0.05-0.01) improved arthritic score; reducing erythema, swelling and joint rigidity, and also significantly (P‚ȧ0.05-0.01) reduced hyperplasia, pannus formation, and exudation of inflammatory cells into synovial spaces. Conclusion: The stem bark extracts of Trichilia monadelpha reduce bone tissue damage and resorption associated with adjuvant-induced arthritis, hence could be useful in managing arthritis in humans.

Key words: arthritic paw radiography, erythema, subchondral erosion, periostitis, osteolysis, Trichilia monadelpha


 
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Pubmed Style

BEN IO, Woode E, Koffuor GA, Boakye-Gyasi E, Titiloye NA. Effects of Trichilia monadelpha (Meliaceae) extracts on bone histomorphology in complete Freundís adjuvant-induced arthritis. J Complement Med Res (Formerly J Intercult Ethnopharmacol). 2017; 6(2): 177-185. doi:10.5455/jice.20170218092913


Web Style

BEN IO, Woode E, Koffuor GA, Boakye-Gyasi E, Titiloye NA. Effects of Trichilia monadelpha (Meliaceae) extracts on bone histomorphology in complete Freundís adjuvant-induced arthritis. http://www.jicep.com/?mno=241254 [Access: February 20, 2018]. doi:10.5455/jice.20170218092913


AMA (American Medical Association) Style

BEN IO, Woode E, Koffuor GA, Boakye-Gyasi E, Titiloye NA. Effects of Trichilia monadelpha (Meliaceae) extracts on bone histomorphology in complete Freundís adjuvant-induced arthritis. J Complement Med Res (Formerly J Intercult Ethnopharmacol). 2017; 6(2): 177-185. doi:10.5455/jice.20170218092913



Vancouver/ICMJE Style

BEN IO, Woode E, Koffuor GA, Boakye-Gyasi E, Titiloye NA. Effects of Trichilia monadelpha (Meliaceae) extracts on bone histomorphology in complete Freundís adjuvant-induced arthritis. J Complement Med Res (Formerly J Intercult Ethnopharmacol). (2017), [cited February 20, 2018]; 6(2): 177-185. doi:10.5455/jice.20170218092913



Harvard Style

BEN, I. O., Woode, E., Koffuor, G. A., Boakye-Gyasi, E. & Titiloye, N. A. (2017) Effects of Trichilia monadelpha (Meliaceae) extracts on bone histomorphology in complete Freundís adjuvant-induced arthritis. J Complement Med Res (Formerly J Intercult Ethnopharmacol), 6 (2), 177-185. doi:10.5455/jice.20170218092913



Turabian Style

BEN, INEMESIT OKON, Eric Woode, George Asumeng Koffuor, Eric Boakye-Gyasi, and Nicholas Akinwale Titiloye. 2017. Effects of Trichilia monadelpha (Meliaceae) extracts on bone histomorphology in complete Freundís adjuvant-induced arthritis. Journal of Complementary Medicine Research (Formerly known as Journal of Intercultural Ethnopharmacology (2012-2017)), 6 (2), 177-185. doi:10.5455/jice.20170218092913



Chicago Style

BEN, INEMESIT OKON, Eric Woode, George Asumeng Koffuor, Eric Boakye-Gyasi, and Nicholas Akinwale Titiloye. "Effects of Trichilia monadelpha (Meliaceae) extracts on bone histomorphology in complete Freundís adjuvant-induced arthritis." Journal of Complementary Medicine Research (Formerly known as Journal of Intercultural Ethnopharmacology (2012-2017)) 6 (2017), 177-185. doi:10.5455/jice.20170218092913



MLA (The Modern Language Association) Style

BEN, INEMESIT OKON, Eric Woode, George Asumeng Koffuor, Eric Boakye-Gyasi, and Nicholas Akinwale Titiloye. "Effects of Trichilia monadelpha (Meliaceae) extracts on bone histomorphology in complete Freundís adjuvant-induced arthritis." Journal of Complementary Medicine Research (Formerly known as Journal of Intercultural Ethnopharmacology (2012-2017)) 6.2 (2017), 177-185. Print. doi:10.5455/jice.20170218092913



APA (American Psychological Association) Style

BEN, I. O., Woode, E., Koffuor, G. A., Boakye-Gyasi, E. & Titiloye, N. A. (2017) Effects of Trichilia monadelpha (Meliaceae) extracts on bone histomorphology in complete Freundís adjuvant-induced arthritis. Journal of Complementary Medicine Research (Formerly known as Journal of Intercultural Ethnopharmacology (2012-2017)), 6 (2), 177-185. doi:10.5455/jice.20170218092913





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