eJManager
 
E-ISSN 2146-8397
 

Original Research Open Access


Geraniin attenuates Naloxone-Precipitated Morphine Withdrawal and Morphine-Induced Tolerance in Mice

Ella Anle Kasanga, Eric Boakye-Gyasi, Robert Peter Biney, James Oppong Kyekyeku, Christian Agyare, Eric Woode.

Abstract
Background and aim: Potentially life-threatening and unpleasant side effects associated with some analgesics has fueled the drive for the search for more analgesics with better side effect profiles. Geraniin, the most dominant secondary metabolite in the aqueous extract of the aerial parts of Phyllanthus muellerianus, has been shown to possess anti-nociceptive properties mediated partly by opioidergic mechanisms. The purpose of this study is to determine whether geraniin exhibits tolerance and if it is able to ameliorate withdrawal signs in naloxone-precipitated morphine withdrawal.
Materials and methods: After chronic treatment of mice with geraniin orally, the formalin test was used to ascertain whether tolerance will develop to its anti-nociceptive effects and if there is morphine-induced tolerance cross-generalization with geraniin. The effect of geraniin on naloxone-precipitated morphine withdrawal signs in morphine dependent mice was also investigated.
Results: Geraniin (3 – 30 mg kg-1) did not produce any tolerant effects after chronic administration and there was also no cross generalization with the tolerant effects of morphine. Geraniin did not induce withdrawal signs but significantly reduced the number of jumps in morphine dependent mice.
Conclusion: Geraniin does not produce any tolerant effects like morphine and also reduced the signs associated with naloxone-precipitated morphine withdrawal in mice.

Key words: muellerianus, naloxone, withdrawal, dependence, geraniin


 
ARTICLE TOOLS
Abstract
PDF Fulltext
Print this article Print this Article
How to cite this articleHow to cite this article
Export to
Export to
Related Records
 Articles by Ella Anle Kasanga
Articles by Eric Boakye-Gyasi
Articles by Robert Peter Biney
Articles by James Oppong Kyekyeku
Articles by Christian Agyare
Articles by Eric Woode
on Google
on Google Scholar
Article Statistics
 Viewed: 1519
Downloaded: 301
Cited: 0

How to Cite this Article
Pubmed Style

Kasanga EA, Boakye-Gyasi E, Biney RP, Kyekyeku JO, Agyare C, Woode E. Geraniin attenuates Naloxone-Precipitated Morphine Withdrawal and Morphine-Induced Tolerance in Mice. J Complement Med Res (Formerly J Intercult Ethnopharmacol). 2017; 6(2): 199-205. doi:10.5455/jice.20161229015413


Web Style

Kasanga EA, Boakye-Gyasi E, Biney RP, Kyekyeku JO, Agyare C, Woode E. Geraniin attenuates Naloxone-Precipitated Morphine Withdrawal and Morphine-Induced Tolerance in Mice. http://www.jicep.com/?mno=245486 [Access: February 20, 2018]. doi:10.5455/jice.20161229015413


AMA (American Medical Association) Style

Kasanga EA, Boakye-Gyasi E, Biney RP, Kyekyeku JO, Agyare C, Woode E. Geraniin attenuates Naloxone-Precipitated Morphine Withdrawal and Morphine-Induced Tolerance in Mice. J Complement Med Res (Formerly J Intercult Ethnopharmacol). 2017; 6(2): 199-205. doi:10.5455/jice.20161229015413



Vancouver/ICMJE Style

Kasanga EA, Boakye-Gyasi E, Biney RP, Kyekyeku JO, Agyare C, Woode E. Geraniin attenuates Naloxone-Precipitated Morphine Withdrawal and Morphine-Induced Tolerance in Mice. J Complement Med Res (Formerly J Intercult Ethnopharmacol). (2017), [cited February 20, 2018]; 6(2): 199-205. doi:10.5455/jice.20161229015413



Harvard Style

Kasanga, E. A., Boakye-Gyasi, E., Biney, R. P., Kyekyeku, J. O., Agyare, C. & Woode, E. (2017) Geraniin attenuates Naloxone-Precipitated Morphine Withdrawal and Morphine-Induced Tolerance in Mice. J Complement Med Res (Formerly J Intercult Ethnopharmacol), 6 (2), 199-205. doi:10.5455/jice.20161229015413



Turabian Style

Kasanga, Ella Anle, Eric Boakye-Gyasi, Robert Peter Biney, James Oppong Kyekyeku, Christian Agyare, and Eric Woode. 2017. Geraniin attenuates Naloxone-Precipitated Morphine Withdrawal and Morphine-Induced Tolerance in Mice. Journal of Complementary Medicine Research (Formerly known as Journal of Intercultural Ethnopharmacology (2012-2017)), 6 (2), 199-205. doi:10.5455/jice.20161229015413



Chicago Style

Kasanga, Ella Anle, Eric Boakye-Gyasi, Robert Peter Biney, James Oppong Kyekyeku, Christian Agyare, and Eric Woode. "Geraniin attenuates Naloxone-Precipitated Morphine Withdrawal and Morphine-Induced Tolerance in Mice." Journal of Complementary Medicine Research (Formerly known as Journal of Intercultural Ethnopharmacology (2012-2017)) 6 (2017), 199-205. doi:10.5455/jice.20161229015413



MLA (The Modern Language Association) Style

Kasanga, Ella Anle, Eric Boakye-Gyasi, Robert Peter Biney, James Oppong Kyekyeku, Christian Agyare, and Eric Woode. "Geraniin attenuates Naloxone-Precipitated Morphine Withdrawal and Morphine-Induced Tolerance in Mice." Journal of Complementary Medicine Research (Formerly known as Journal of Intercultural Ethnopharmacology (2012-2017)) 6.2 (2017), 199-205. Print. doi:10.5455/jice.20161229015413



APA (American Psychological Association) Style

Kasanga, E. A., Boakye-Gyasi, E., Biney, R. P., Kyekyeku, J. O., Agyare, C. & Woode, E. (2017) Geraniin attenuates Naloxone-Precipitated Morphine Withdrawal and Morphine-Induced Tolerance in Mice. Journal of Complementary Medicine Research (Formerly known as Journal of Intercultural Ethnopharmacology (2012-2017)), 6 (2), 199-205. doi:10.5455/jice.20161229015413





Most Viewed Articles
  • Role of Cyperus rotundus oil in decreasing hair growth
    GHADA FAROUK ABD EL-KAREAM
    J Complement Med Res (Formerly J Intercult Ethnopharmacol). 2012; 1(2): 111-118
    » Abstract & References » doi: 10.5455/jice.20120626100304

  • Ethno-dentistry: popular medicinal plants used for dental diseases in India
    Amit Bhardwaj, Shalu Verma Bhardwaj
    J Complement Med Res (Formerly J Intercult Ethnopharmacol). 2012; 1(1): 62-65
    » Abstract & References » doi: 10.5455/jice.20120322035152

  • Studies with Myrtus communis L.: Anticancer Properties
    Recai Ogur
    J Complement Med Res (Formerly J Intercult Ethnopharmacol). 2014; 3(4): 135-137
    » Abstract & References » doi: 10.5455/jice.20140803044831

  • Total phenolic, flavonoids and tannin contents in different extracts of Artemisia absinthium
    Rajeev Singh, Pawan Kumar Verma, Gagandeep Singh
    J Complement Med Res (Formerly J Intercult Ethnopharmacol). 2012; 1(2): 101-104
    » Abstract & References » doi: 10.5455/jice.20120525014326

  • Antimicrobial and phytochemical evaluation of the leaf, stem bark and root extracts of Cyathula prostrata (L) Blume against some human pathogens
    Gideon Ikechukwu Ogu, Williams Omotola Tanimowo, Perpetua Ugonna Nwachukwu, Bright Esegbuyota Igere
    J Complement Med Res (Formerly J Intercult Ethnopharmacol). 2012; 1(1): 35-43
    » Abstract & References » doi: 10.5455/jice.20120407085952

  • Herbal Antibacterials: A Review
    Chirag Modi, Shailesh Mody, Hitesh Patel, Ghanshyam Dudhatra, Avinash Kumar, Madhavi Awale
    J Complement Med Res (Formerly J Intercult Ethnopharmacol). 2012; 1(1): 52-61
    » Abstract & References » doi: 10.5455/jice.20120207113423

  • Preliminary phytochemical screening and evaluation of antibacterial activity of Dichrocepala integrifolia (L.f) O. kuntze
    Tesfaye Mohammed, Chalachew Teshale
    J Complement Med Res (Formerly J Intercult Ethnopharmacol). 2012; 1(1): 30-34
    » Abstract & References » doi: 10.5455/jice.20120401054654

  • Medicinal plants with potential anti-arthritic activity:
    Manjusha Choudhary, Vipin Kumar, Hitesh Malhotra, Surender Singh
    J Complement Med Res (Formerly J Intercult Ethnopharmacol). 2015; 4(2): 147-179
    » Abstract & References » doi: 10.5455/jice.20150313021918

  • Phytochemical and antibacterial activity of the extracts of Fagara zanthoxyloides on selected cariogenic and enteric bacterial isolates
    Martins Ajibade Adefisoye, Kwashie AjibadeAko-Nai, Mary Adejumoke Bisi-Johnson
    J Complement Med Res (Formerly J Intercult Ethnopharmacol). 2012; 1(1): 1-6
    » Abstract & References » doi: 10.5455/jice.55-1333123486

  • Effect of Momordica charantia (bitter melon) on serum glucose level and various protein parameters in acetaminophen intoxicated rabbits
    Kanwal Zahra, Muhammad Imran Sohail, Muhammad Anwar Malik
    J Complement Med Res (Formerly J Intercult Ethnopharmacol). 2012; 1(1): 7-12
    » Abstract & References » doi: 10.5455/jice.20120403013109

  • Most Downloaded
  • Studies with Myrtus communis L.: Anticancer Properties
    Recai Ogur
    J Complement Med Res (Formerly J Intercult Ethnopharmacol). 2014; 3(4): 135-137
    » Abstract & References » doi: 10.5455/jice.20140803044831

  • Total phenolic, flavonoids and tannin contents in different extracts of Artemisia absinthium
    Rajeev Singh, Pawan Kumar Verma, Gagandeep Singh
    J Complement Med Res (Formerly J Intercult Ethnopharmacol). 2012; 1(2): 101-104
    » Abstract & References » doi: 10.5455/jice.20120525014326

  • Herbal Antibacterials: A Review
    Chirag Modi, Shailesh Mody, Hitesh Patel, Ghanshyam Dudhatra, Avinash Kumar, Madhavi Awale
    J Complement Med Res (Formerly J Intercult Ethnopharmacol). 2012; 1(1): 52-61
    » Abstract & References » doi: 10.5455/jice.20120207113423

  • Ethno-dentistry: popular medicinal plants used for dental diseases in India
    Amit Bhardwaj, Shalu Verma Bhardwaj
    J Complement Med Res (Formerly J Intercult Ethnopharmacol). 2012; 1(1): 62-65
    » Abstract & References » doi: 10.5455/jice.20120322035152

  • Antimicrobial and phytochemical evaluation of the leaf, stem bark and root extracts of Cyathula prostrata (L) Blume against some human pathogens
    Gideon Ikechukwu Ogu, Williams Omotola Tanimowo, Perpetua Ugonna Nwachukwu, Bright Esegbuyota Igere
    J Complement Med Res (Formerly J Intercult Ethnopharmacol). 2012; 1(1): 35-43
    » Abstract & References » doi: 10.5455/jice.20120407085952

  • Role of Cyperus rotundus oil in decreasing hair growth
    GHADA FAROUK ABD EL-KAREAM
    J Complement Med Res (Formerly J Intercult Ethnopharmacol). 2012; 1(2): 111-118
    » Abstract & References » doi: 10.5455/jice.20120626100304

  • A review on ethnopharmacological potential of Aloe vera L.
    Md. Shamim Hossain, A.N.M Mamun-Or-Rashid, Nayeem Md. Towfique, Monokesh Kumer Sen
    J Complement Med Res (Formerly J Intercult Ethnopharmacol). 2013; 2(2): 113-120
    » Abstract & References » doi: 10.5455/jice.20130612035300

  • Use of Aqueous Extract of Corn Silk in the Treatment of Urinary Tract Infection
    Ahmed Salih Sahib, Imad Hashim Mohammed, Saba Jasim Hamdan
    J Complement Med Res (Formerly J Intercult Ethnopharmacol). 2012; 1(2): 93-96
    » Abstract & References » doi: 10.5455/jice.20120525123150

  • Preliminary phytochemical screening and evaluation of antibacterial activity of Dichrocepala integrifolia (L.f) O. kuntze
    Tesfaye Mohammed, Chalachew Teshale
    J Complement Med Res (Formerly J Intercult Ethnopharmacol). 2012; 1(1): 30-34
    » Abstract & References » doi: 10.5455/jice.20120401054654

  • Phytochemical and antibacterial activity of the extracts of Fagara zanthoxyloides on selected cariogenic and enteric bacterial isolates
    Martins Ajibade Adefisoye, Kwashie AjibadeAko-Nai, Mary Adejumoke Bisi-Johnson
    J Complement Med Res (Formerly J Intercult Ethnopharmacol). 2012; 1(1): 1-6
    » Abstract & References » doi: 10.5455/jice.55-1333123486

  • Most Cited Articles
  • Total phenolic, flavonoids and tannin contents in different extracts of Artemisia absinthium
    Rajeev Singh, Pawan Kumar Verma, Gagandeep Singh
    J Complement Med Res (Formerly J Intercult Ethnopharmacol). 2012; 1(2): 101-104
    » Abstract & References » doi: 10.5455/jice.20120525014326
    Cited : 28 times [Click to see citing articles]

  • Antimicrobial and phytochemical evaluation of the leaf, stem bark and root extracts of Cyathula prostrata (L) Blume against some human pathogens
    Gideon Ikechukwu Ogu, Williams Omotola Tanimowo, Perpetua Ugonna Nwachukwu, Bright Esegbuyota Igere
    J Complement Med Res (Formerly J Intercult Ethnopharmacol). 2012; 1(1): 35-43
    » Abstract & References » doi: 10.5455/jice.20120407085952
    Cited : 11 times [Click to see citing articles]

  • Some pharmacological effects of cinnamon and ginger herbs in obese diabetic rats
    Mostafa Abbas Shalaby, Hamed Yahya Saifan
    J Complement Med Res (Formerly J Intercult Ethnopharmacol). 2014; 3(4): 144-149
    » Abstract & References » doi: 10.5455/jice.20140818050741
    Cited : 11 times [Click to see citing articles]

  • Guava leaves polyphenolics-rich extract inhibits vital enzymes implicated in gout and hypertension in vitro
    Emmanuel Anyachukwu Irondi, Samson Olalekan Agboola, Ganiyu Oboh, Aline Augusti Boligon, Margareth Linde Athayde, Francis O. Shode
    J Complement Med Res (Formerly J Intercult Ethnopharmacol). 2016; 5(2): 122-130
    » Abstract & References » doi: 10.5455/jice.20160321115402
    Cited : 11 times [Click to see citing articles]

  • Analgesic, Anti-inflammatory and Antihyperlipidemic Activities of Commiphora molmol Extract (Myrrh)
    Mostafa Abbas Shalaby, Ashraf Abd-Elkhalik Hammouda
    J Complement Med Res (Formerly J Intercult Ethnopharmacol). 2014; 3(2): 56-62
    » Abstract & References » doi: 10.5455/jice.20140130015014
    Cited : 9 times [Click to see citing articles]

  • Potential antimalarials from African natural products: a review
    Bashir Lawal, Oluwatosin Kudirat Shittu, Adamu Yusuf Kabiru, Ali Audu Jigam, Maimuna Bello Umar, Eustace Bonghan Berinyuy, Blessing Uchenna Alozieuwa
    J Complement Med Res (Formerly J Intercult Ethnopharmacol). 2015; 4(4): 318-343
    » Abstract & References » doi: 10.5455/jice.20150928102856
    Cited : 8 times [Click to see citing articles]

  • Herbal medicine use among Turkish patients with chronic diseases
    Münevver Tulunay, Cenk Aypak, Hülya Yıkılkan, Süleyman Görpelioğlu
    J Complement Med Res (Formerly J Intercult Ethnopharmacol). 2015; 4(3): 217-220
    » Abstract & References » doi: 10.5455/jice.20150623090040
    Cited : 7 times [Click to see citing articles]

  • Is there a role for homeopathy in breast cancer surgery? A first randomized clinical trial on treatment with Arnica montana to reduce postoperative seroma and bleeding in patients undergoing total mastectomy
    Luca Sorrentino, Salvatore Piraneo, Eliana Riggio, Silvia Basilicò, Alessandra Sartani, Daniela Bossi, Fabio Corsi
    J Complement Med Res (Formerly J Intercult Ethnopharmacol). 2017; 6(1): 1-8
    » Abstract » doi: 10.5455/jice.20161229055245
    Cited : 6 times [Click to see citing articles]

  • Study of antinociceptive and anti-inflammatory activities of certain Iranian medicinal plants
    Fariba Sharififar, Payam Khazaeli, Narguess Alli, Elham Talebian, Raheleh Zarehshahi, Shivasadat Amiri
    J Complement Med Res (Formerly J Intercult Ethnopharmacol). 2012; 1(1): 19-24
    » Abstract & References » doi: 10.5455/jice.20120227104636
    Cited : 5 times [Click to see citing articles]

  • Preliminary phytochemical screening and evaluation of antibacterial activity of Dichrocepala integrifolia (L.f) O. kuntze
    Tesfaye Mohammed, Chalachew Teshale
    J Complement Med Res (Formerly J Intercult Ethnopharmacol). 2012; 1(1): 30-34
    » Abstract & References » doi: 10.5455/jice.20120401054654
    Cited : 5 times [Click to see citing articles]