eJManager
 
E-ISSN 2146-8397
 

Original Research Open Access


Toxicity status and anti-ulcerative potential of Sanseviera trifasciata leaf extract in wistar rats

Osaseaga Macdonald Ighodaro, Abiola Muhammad Adeosun, Barinemene Francis Ojiko, Abeeb Taiwo Akorede, Oyindamola Fuyi-Williams.

Abstract
Aims: The lethal dose (LD50) and anti-ulcerative potentials of Sansevieria trifasciata (ST) leaf extract were investigated. Methods: LD50 was determined through two routes of administration (intraperitoneal and oral) using the method of Lorke. The anti-ulcerative activity was evaluated in indomethacin-induced ulcer model (40 mg/kg BW, i.p, single dose) against a reference drug, Cimetidine (100 mg/kg BW, per ox (p.o)). ST was assessed at two different doses (200 and 400 mg/kg BW, p.o). Treatments were done twice daily at 8 h interval for 7 days prior to indomethacin injection. Results: The intraperitoneal (i.p) LD50 was determined as 774.60 mg/kg BW and oral administration of the extract at 18,000 mg/kg BW dosage did not cause any negative behavioral changes in the animals, and no mortality was recorded after 24h of the experiment. ST- pre-treated animals showed some improvement against indomethacin-induced ulceration. The extract was able to an extent prevent indomethacin-induced reduction in gastric volume (36.1 %), free acidity (55.3 %), total acidity (35.6 %) while minimizing increase in pH by (13.3 %). Moreover, the extract showed 17.92% and 14.96 % ulcer-protective ability at 200 and 400 mg/kg BW respectively. The phytochemical analysis of ST extract revealed the presence of phytoconstituents such as glycosides, saponins, flavonoids, terpenoids, alkaloids, tannins, Anthraquinone and glycosides. Conclusions: Sansevieria trifasciata apparently has a promising anti-ulcerative potential, and is safe for use in folk medicine. This valuable medicinal property is probably due to the array of important phytochemicals contained in the plant as observed in this study. However, further study involving bioassay-guided identification of the main anti-ulcerative compound in ST is required to establish the use of the plant as a viable anti-ulcerative agent.

Key words: Sansevieria trifasciata; gastric ulcer; toxicity status; indomethacin; Wistar rats


 
ARTICLE TOOLS
Abstract
PDF Fulltext
Print this article Print this Article
How to cite this articleHow to cite this article
Export to
Export to
Related Records
 Articles by Osaseaga Macdonald Ighodaro
Articles by Abiola Muhammad Adeosun
Articles by Barinemene Francis Ojiko
Articles by Abeeb Taiwo Akorede
Articles by Oyindamola Fuyi-Williams
on Google
on Google Scholar
Article Statistics
 Viewed: 1645
Downloaded: 407
Cited: 0

How to Cite this Article
Pubmed Style

Ighodaro OM, Adeosun AM, Ojiko BF, Akorede AT, Fuyi-Williams O. Toxicity status and anti-ulcerative potential of Sanseviera trifasciata leaf extract in wistar rats. J Complement Med Res (Formerly J Intercult Ethnopharmacol). 2017; 6(2): 234-239. doi:10.5455/jice.20170421103553


Web Style

Ighodaro OM, Adeosun AM, Ojiko BF, Akorede AT, Fuyi-Williams O. Toxicity status and anti-ulcerative potential of Sanseviera trifasciata leaf extract in wistar rats. http://www.jicep.com/?mno=257001 [Access: February 20, 2018]. doi:10.5455/jice.20170421103553


AMA (American Medical Association) Style

Ighodaro OM, Adeosun AM, Ojiko BF, Akorede AT, Fuyi-Williams O. Toxicity status and anti-ulcerative potential of Sanseviera trifasciata leaf extract in wistar rats. J Complement Med Res (Formerly J Intercult Ethnopharmacol). 2017; 6(2): 234-239. doi:10.5455/jice.20170421103553



Vancouver/ICMJE Style

Ighodaro OM, Adeosun AM, Ojiko BF, Akorede AT, Fuyi-Williams O. Toxicity status and anti-ulcerative potential of Sanseviera trifasciata leaf extract in wistar rats. J Complement Med Res (Formerly J Intercult Ethnopharmacol). (2017), [cited February 20, 2018]; 6(2): 234-239. doi:10.5455/jice.20170421103553



Harvard Style

Ighodaro, O. M., Adeosun, A. M., Ojiko, B. F., Akorede, A. T. & Fuyi-Williams, O. (2017) Toxicity status and anti-ulcerative potential of Sanseviera trifasciata leaf extract in wistar rats. J Complement Med Res (Formerly J Intercult Ethnopharmacol), 6 (2), 234-239. doi:10.5455/jice.20170421103553



Turabian Style

Ighodaro, Osaseaga Macdonald, Abiola Muhammad Adeosun, Barinemene Francis Ojiko, Abeeb Taiwo Akorede, and Oyindamola Fuyi-Williams. 2017. Toxicity status and anti-ulcerative potential of Sanseviera trifasciata leaf extract in wistar rats. Journal of Complementary Medicine Research (Formerly known as Journal of Intercultural Ethnopharmacology (2012-2017)), 6 (2), 234-239. doi:10.5455/jice.20170421103553



Chicago Style

Ighodaro, Osaseaga Macdonald, Abiola Muhammad Adeosun, Barinemene Francis Ojiko, Abeeb Taiwo Akorede, and Oyindamola Fuyi-Williams. "Toxicity status and anti-ulcerative potential of Sanseviera trifasciata leaf extract in wistar rats." Journal of Complementary Medicine Research (Formerly known as Journal of Intercultural Ethnopharmacology (2012-2017)) 6 (2017), 234-239. doi:10.5455/jice.20170421103553



MLA (The Modern Language Association) Style

Ighodaro, Osaseaga Macdonald, Abiola Muhammad Adeosun, Barinemene Francis Ojiko, Abeeb Taiwo Akorede, and Oyindamola Fuyi-Williams. "Toxicity status and anti-ulcerative potential of Sanseviera trifasciata leaf extract in wistar rats." Journal of Complementary Medicine Research (Formerly known as Journal of Intercultural Ethnopharmacology (2012-2017)) 6.2 (2017), 234-239. Print. doi:10.5455/jice.20170421103553



APA (American Psychological Association) Style

Ighodaro, O. M., Adeosun, A. M., Ojiko, B. F., Akorede, A. T. & Fuyi-Williams, O. (2017) Toxicity status and anti-ulcerative potential of Sanseviera trifasciata leaf extract in wistar rats. Journal of Complementary Medicine Research (Formerly known as Journal of Intercultural Ethnopharmacology (2012-2017)), 6 (2), 234-239. doi:10.5455/jice.20170421103553





Most Viewed Articles
  • Role of Cyperus rotundus oil in decreasing hair growth
    GHADA FAROUK ABD EL-KAREAM
    J Complement Med Res (Formerly J Intercult Ethnopharmacol). 2012; 1(2): 111-118
    » Abstract & References » doi: 10.5455/jice.20120626100304

  • Ethno-dentistry: popular medicinal plants used for dental diseases in India
    Amit Bhardwaj, Shalu Verma Bhardwaj
    J Complement Med Res (Formerly J Intercult Ethnopharmacol). 2012; 1(1): 62-65
    » Abstract & References » doi: 10.5455/jice.20120322035152

  • Studies with Myrtus communis L.: Anticancer Properties
    Recai Ogur
    J Complement Med Res (Formerly J Intercult Ethnopharmacol). 2014; 3(4): 135-137
    » Abstract & References » doi: 10.5455/jice.20140803044831

  • Total phenolic, flavonoids and tannin contents in different extracts of Artemisia absinthium
    Rajeev Singh, Pawan Kumar Verma, Gagandeep Singh
    J Complement Med Res (Formerly J Intercult Ethnopharmacol). 2012; 1(2): 101-104
    » Abstract & References » doi: 10.5455/jice.20120525014326

  • Antimicrobial and phytochemical evaluation of the leaf, stem bark and root extracts of Cyathula prostrata (L) Blume against some human pathogens
    Gideon Ikechukwu Ogu, Williams Omotola Tanimowo, Perpetua Ugonna Nwachukwu, Bright Esegbuyota Igere
    J Complement Med Res (Formerly J Intercult Ethnopharmacol). 2012; 1(1): 35-43
    » Abstract & References » doi: 10.5455/jice.20120407085952

  • Herbal Antibacterials: A Review
    Chirag Modi, Shailesh Mody, Hitesh Patel, Ghanshyam Dudhatra, Avinash Kumar, Madhavi Awale
    J Complement Med Res (Formerly J Intercult Ethnopharmacol). 2012; 1(1): 52-61
    » Abstract & References » doi: 10.5455/jice.20120207113423

  • Preliminary phytochemical screening and evaluation of antibacterial activity of Dichrocepala integrifolia (L.f) O. kuntze
    Tesfaye Mohammed, Chalachew Teshale
    J Complement Med Res (Formerly J Intercult Ethnopharmacol). 2012; 1(1): 30-34
    » Abstract & References » doi: 10.5455/jice.20120401054654

  • Medicinal plants with potential anti-arthritic activity:
    Manjusha Choudhary, Vipin Kumar, Hitesh Malhotra, Surender Singh
    J Complement Med Res (Formerly J Intercult Ethnopharmacol). 2015; 4(2): 147-179
    » Abstract & References » doi: 10.5455/jice.20150313021918

  • Phytochemical and antibacterial activity of the extracts of Fagara zanthoxyloides on selected cariogenic and enteric bacterial isolates
    Martins Ajibade Adefisoye, Kwashie AjibadeAko-Nai, Mary Adejumoke Bisi-Johnson
    J Complement Med Res (Formerly J Intercult Ethnopharmacol). 2012; 1(1): 1-6
    » Abstract & References » doi: 10.5455/jice.55-1333123486

  • Effect of Momordica charantia (bitter melon) on serum glucose level and various protein parameters in acetaminophen intoxicated rabbits
    Kanwal Zahra, Muhammad Imran Sohail, Muhammad Anwar Malik
    J Complement Med Res (Formerly J Intercult Ethnopharmacol). 2012; 1(1): 7-12
    » Abstract & References » doi: 10.5455/jice.20120403013109

  • Most Downloaded
  • Studies with Myrtus communis L.: Anticancer Properties
    Recai Ogur
    J Complement Med Res (Formerly J Intercult Ethnopharmacol). 2014; 3(4): 135-137
    » Abstract & References » doi: 10.5455/jice.20140803044831

  • Total phenolic, flavonoids and tannin contents in different extracts of Artemisia absinthium
    Rajeev Singh, Pawan Kumar Verma, Gagandeep Singh
    J Complement Med Res (Formerly J Intercult Ethnopharmacol). 2012; 1(2): 101-104
    » Abstract & References » doi: 10.5455/jice.20120525014326

  • Herbal Antibacterials: A Review
    Chirag Modi, Shailesh Mody, Hitesh Patel, Ghanshyam Dudhatra, Avinash Kumar, Madhavi Awale
    J Complement Med Res (Formerly J Intercult Ethnopharmacol). 2012; 1(1): 52-61
    » Abstract & References » doi: 10.5455/jice.20120207113423

  • Ethno-dentistry: popular medicinal plants used for dental diseases in India
    Amit Bhardwaj, Shalu Verma Bhardwaj
    J Complement Med Res (Formerly J Intercult Ethnopharmacol). 2012; 1(1): 62-65
    » Abstract & References » doi: 10.5455/jice.20120322035152

  • Antimicrobial and phytochemical evaluation of the leaf, stem bark and root extracts of Cyathula prostrata (L) Blume against some human pathogens
    Gideon Ikechukwu Ogu, Williams Omotola Tanimowo, Perpetua Ugonna Nwachukwu, Bright Esegbuyota Igere
    J Complement Med Res (Formerly J Intercult Ethnopharmacol). 2012; 1(1): 35-43
    » Abstract & References » doi: 10.5455/jice.20120407085952

  • Role of Cyperus rotundus oil in decreasing hair growth
    GHADA FAROUK ABD EL-KAREAM
    J Complement Med Res (Formerly J Intercult Ethnopharmacol). 2012; 1(2): 111-118
    » Abstract & References » doi: 10.5455/jice.20120626100304

  • A review on ethnopharmacological potential of Aloe vera L.
    Md. Shamim Hossain, A.N.M Mamun-Or-Rashid, Nayeem Md. Towfique, Monokesh Kumer Sen
    J Complement Med Res (Formerly J Intercult Ethnopharmacol). 2013; 2(2): 113-120
    » Abstract & References » doi: 10.5455/jice.20130612035300

  • Use of Aqueous Extract of Corn Silk in the Treatment of Urinary Tract Infection
    Ahmed Salih Sahib, Imad Hashim Mohammed, Saba Jasim Hamdan
    J Complement Med Res (Formerly J Intercult Ethnopharmacol). 2012; 1(2): 93-96
    » Abstract & References » doi: 10.5455/jice.20120525123150

  • Preliminary phytochemical screening and evaluation of antibacterial activity of Dichrocepala integrifolia (L.f) O. kuntze
    Tesfaye Mohammed, Chalachew Teshale
    J Complement Med Res (Formerly J Intercult Ethnopharmacol). 2012; 1(1): 30-34
    » Abstract & References » doi: 10.5455/jice.20120401054654

  • Phytochemical and antibacterial activity of the extracts of Fagara zanthoxyloides on selected cariogenic and enteric bacterial isolates
    Martins Ajibade Adefisoye, Kwashie AjibadeAko-Nai, Mary Adejumoke Bisi-Johnson
    J Complement Med Res (Formerly J Intercult Ethnopharmacol). 2012; 1(1): 1-6
    » Abstract & References » doi: 10.5455/jice.55-1333123486

  • Most Cited Articles
  • Total phenolic, flavonoids and tannin contents in different extracts of Artemisia absinthium
    Rajeev Singh, Pawan Kumar Verma, Gagandeep Singh
    J Complement Med Res (Formerly J Intercult Ethnopharmacol). 2012; 1(2): 101-104
    » Abstract & References » doi: 10.5455/jice.20120525014326
    Cited : 28 times [Click to see citing articles]

  • Antimicrobial and phytochemical evaluation of the leaf, stem bark and root extracts of Cyathula prostrata (L) Blume against some human pathogens
    Gideon Ikechukwu Ogu, Williams Omotola Tanimowo, Perpetua Ugonna Nwachukwu, Bright Esegbuyota Igere
    J Complement Med Res (Formerly J Intercult Ethnopharmacol). 2012; 1(1): 35-43
    » Abstract & References » doi: 10.5455/jice.20120407085952
    Cited : 11 times [Click to see citing articles]

  • Some pharmacological effects of cinnamon and ginger herbs in obese diabetic rats
    Mostafa Abbas Shalaby, Hamed Yahya Saifan
    J Complement Med Res (Formerly J Intercult Ethnopharmacol). 2014; 3(4): 144-149
    » Abstract & References » doi: 10.5455/jice.20140818050741
    Cited : 11 times [Click to see citing articles]

  • Guava leaves polyphenolics-rich extract inhibits vital enzymes implicated in gout and hypertension in vitro
    Emmanuel Anyachukwu Irondi, Samson Olalekan Agboola, Ganiyu Oboh, Aline Augusti Boligon, Margareth Linde Athayde, Francis O. Shode
    J Complement Med Res (Formerly J Intercult Ethnopharmacol). 2016; 5(2): 122-130
    » Abstract & References » doi: 10.5455/jice.20160321115402
    Cited : 11 times [Click to see citing articles]

  • Analgesic, Anti-inflammatory and Antihyperlipidemic Activities of Commiphora molmol Extract (Myrrh)
    Mostafa Abbas Shalaby, Ashraf Abd-Elkhalik Hammouda
    J Complement Med Res (Formerly J Intercult Ethnopharmacol). 2014; 3(2): 56-62
    » Abstract & References » doi: 10.5455/jice.20140130015014
    Cited : 9 times [Click to see citing articles]

  • Potential antimalarials from African natural products: a review
    Bashir Lawal, Oluwatosin Kudirat Shittu, Adamu Yusuf Kabiru, Ali Audu Jigam, Maimuna Bello Umar, Eustace Bonghan Berinyuy, Blessing Uchenna Alozieuwa
    J Complement Med Res (Formerly J Intercult Ethnopharmacol). 2015; 4(4): 318-343
    » Abstract & References » doi: 10.5455/jice.20150928102856
    Cited : 8 times [Click to see citing articles]

  • Herbal medicine use among Turkish patients with chronic diseases
    Münevver Tulunay, Cenk Aypak, Hülya Yıkılkan, Süleyman Görpelioğlu
    J Complement Med Res (Formerly J Intercult Ethnopharmacol). 2015; 4(3): 217-220
    » Abstract & References » doi: 10.5455/jice.20150623090040
    Cited : 7 times [Click to see citing articles]

  • Is there a role for homeopathy in breast cancer surgery? A first randomized clinical trial on treatment with Arnica montana to reduce postoperative seroma and bleeding in patients undergoing total mastectomy
    Luca Sorrentino, Salvatore Piraneo, Eliana Riggio, Silvia Basilicò, Alessandra Sartani, Daniela Bossi, Fabio Corsi
    J Complement Med Res (Formerly J Intercult Ethnopharmacol). 2017; 6(1): 1-8
    » Abstract » doi: 10.5455/jice.20161229055245
    Cited : 6 times [Click to see citing articles]

  • Study of antinociceptive and anti-inflammatory activities of certain Iranian medicinal plants
    Fariba Sharififar, Payam Khazaeli, Narguess Alli, Elham Talebian, Raheleh Zarehshahi, Shivasadat Amiri
    J Complement Med Res (Formerly J Intercult Ethnopharmacol). 2012; 1(1): 19-24
    » Abstract & References » doi: 10.5455/jice.20120227104636
    Cited : 5 times [Click to see citing articles]

  • Preliminary phytochemical screening and evaluation of antibacterial activity of Dichrocepala integrifolia (L.f) O. kuntze
    Tesfaye Mohammed, Chalachew Teshale
    J Complement Med Res (Formerly J Intercult Ethnopharmacol). 2012; 1(1): 30-34
    » Abstract & References » doi: 10.5455/jice.20120401054654
    Cited : 5 times [Click to see citing articles]