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Analgesic activity of Nyctanthes arbor-tristis leaves in rodents

Chaitali Pattanayak, Pratyay Pratim Datta.

Cited by (1)

Abstract
Aim: Traditional medicine practitioners use leaf extract of Nyctanthes arbor-tristis for symptomatic relief of arthritis. Studies indicate the anti-inflammatory effect of this extract. The objective of the present study was to investigate the analgesic effect of leaves of Nyctanthes arbor-tristis linn in rodents.
Methods: The leaf extract was prepared by “maceration” with 90% ethanol at room temperature, filtered and the filtrate evaporated to dryness. The extract was suspended in Tween 80 and used intra peritoneally in rodents. Peripheral analgesic activity of the extract at doses 100, 200, 400 mg/kg was evaluated in mice using acetic acid induced writhing test, central analgesic activity was tested in rats using tail flick latency test.
Results: The leaf extract of Nyctanthes arbor-tristis produced significant analgesic activity in a dose dependent manner (both peripheral and central at doses 200 mg/kg and 400 mg/kg). But when compared to the standard drugs (aspirin for peripheral analgesia and pethidine for central analgesia) the efficacy of the test drug was found to be inferior even at highest dose (400 mg/kg). The onset of action of the test drug was found to be between 30 minutes to one hour and duration of action was up to three hours in central analgesia and significant peripheral analgesia was seen even after four hours of administration of NALE at 400 mg/kg dose.
Conclusion: This study demonstrates the potential analgesic effect of Nyctanthes arbor-tristis leaf which supports the claim of traditional medicine practitioners.

Key words: Nyctanthes arbor-tristis, analgesic, tail flick latency, pethidine.


 
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This Article Cited By the following articles

Effect of Nyctanthes arbor tristis leaf extract against scopolamine-induced cognitive impairment in rats
2015; 60(4): .

1
 

How to Cite this Article
Pubmed Style

Pattanayak C, Datta PP. [Analgesic activity of Nyctanthes arbor-tristis leaves in rodents]. J Intercult Ethnopharmacol. 2013; 2(2): 105-112. . doi:10.5455/jice.20130312093742


Web Style

Pattanayak C, Datta PP. [Analgesic activity of Nyctanthes arbor-tristis leaves in rodents]. http://www.jicep.com/?mno=31526 [Access: January 23, 2018]. . doi:10.5455/jice.20130312093742


AMA (American Medical Association) Style

Pattanayak C, Datta PP. [Analgesic activity of Nyctanthes arbor-tristis leaves in rodents]. J Intercult Ethnopharmacol. 2013; 2(2): 105-112. . doi:10.5455/jice.20130312093742



Vancouver/ICMJE Style

Pattanayak C, Datta PP. [Analgesic activity of Nyctanthes arbor-tristis leaves in rodents]. J Intercult Ethnopharmacol. (2013), [cited January 23, 2018]; 2(2): 105-112. . doi:10.5455/jice.20130312093742



Harvard Style

Pattanayak, C. & Datta, P. P. (2013) [Analgesic activity of Nyctanthes arbor-tristis leaves in rodents]. J Intercult Ethnopharmacol, 2 (2), 105-112. . doi:10.5455/jice.20130312093742



Turabian Style

Pattanayak, Chaitali, and Pratyay Pratim Datta. 2013. [Analgesic activity of Nyctanthes arbor-tristis leaves in rodents]. Journal of Intercultural Ethnopharmacology, 2 (2), 105-112. . doi:10.5455/jice.20130312093742



Chicago Style

Pattanayak, Chaitali, and Pratyay Pratim Datta. "[Analgesic activity of Nyctanthes arbor-tristis leaves in rodents]." Journal of Intercultural Ethnopharmacology 2 (2013), 105-112. . doi:10.5455/jice.20130312093742



MLA (The Modern Language Association) Style

Pattanayak, Chaitali, and Pratyay Pratim Datta. "[Analgesic activity of Nyctanthes arbor-tristis leaves in rodents]." Journal of Intercultural Ethnopharmacology 2.2 (2013), 105-112. Print.. doi:10.5455/jice.20130312093742



APA (American Psychological Association) Style

Pattanayak, C. & Datta, P. P. (2013) [Analgesic activity of Nyctanthes arbor-tristis leaves in rodents]. Journal of Intercultural Ethnopharmacology, 2 (2), 105-112. . doi:10.5455/jice.20130312093742





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