Protective effects of polyphenol-rich extracts of Glyphaea brevis against oxidative stress in streptozotocin-induced diabetic rats

*William Dakam; Christine Fernande Nyangono Biyegue; Francoise Raissa Ntentie; Julius Enyong Oben

doi:10.5455/jcmr.2022.13.02.21

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J Complement Med Res. 2022; 13(2): 109-118

doi: 10.5455/jcmr.2022.13.02.21

Protective effects of polyphenol-rich extracts of Glyphaea brevis against oxidative stress in streptozotocin-induced diabetic rats

*William Dakam, Christine Fernande Nyangono Biyegue, Francoise Raissa Ntentie, Julius Enyong Oben.

Abstract
Background and Objective: Diabetes mellitus and its oxidative complications are progressing around the world and plant-based products appear to be promising alternative treatments. The present study aimed to evaluate the antioxidant potential of the leaves of Glyphaea brevis (Tiliaceae) in an experimental model of diabetic rats.
Materials and Methods: Diabetes mellitus was induced by intravenous injection of streptozotocin (STZ). Leaf aqueous and hydroethanolic extracts (AE and HEE respectively) were given daily at doses of 250 and 500 mg/kg by gastric intubation for 30 days. Antioxidant status of rats was determined in extracellular as well as in intracellular compartments by assessing ferric-reducing antioxidant power, enzymatic antioxidants (catalase, superoxide dismutase, and glutathione peroxidase) and non-enzymatic antioxidants (protein thiols).
Results: As compared with untreated diabetic rats, administration of extracts led to significantly higher values of ferric-reducing antioxidant power, enzymatic and non-enzymatic antioxidants in all compartments.
Conclusion: These results suggest that G. brevis extracts have antioxidant activity that could find applications in the management of oxidative complications of diabetes mellitus.

Key words: antioxidant; diabetes mellitus; Glyphaea brevis; oxidative stress; polyphenols

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Pubmed Style

Dakam W, CFNB, FRN, Oben JE. Protective effects of polyphenol-rich extracts of Glyphaea brevis against oxidative stress in streptozotocin-induced diabetic rats. J Complement Med Res. 2022; 13(2): 109-118. doi:10.5455/jcmr.2022.13.02.21

Web Style

Dakam W, CFNB, FRN, Oben JE. Protective effects of polyphenol-rich extracts of Glyphaea brevis against oxidative stress in streptozotocin-induced diabetic rats. https://www.jocmr.com/?mno=101887 [Access: June 24, 2022]. doi:10.5455/jcmr.2022.13.02.21

AMA (American Medical Association) Style

Dakam W, CFNB, FRN, Oben JE. Protective effects of polyphenol-rich extracts of Glyphaea brevis against oxidative stress in streptozotocin-induced diabetic rats. J Complement Med Res. 2022; 13(2): 109-118. doi:10.5455/jcmr.2022.13.02.21

Vancouver/ICMJE Style

Dakam W, CFNB, FRN, Oben JE. Protective effects of polyphenol-rich extracts of Glyphaea brevis against oxidative stress in streptozotocin-induced diabetic rats. J Complement Med Res. (2022), [cited June 24, 2022]; 13(2): 109-118. doi:10.5455/jcmr.2022.13.02.21

Harvard Style

Dakam, W., , . C. F. N. B., , . F. R. N. & Oben, . J. E. (2022) Protective effects of polyphenol-rich extracts of Glyphaea brevis against oxidative stress in streptozotocin-induced diabetic rats. J Complement Med Res, 13 (2), 109-118. doi:10.5455/jcmr.2022.13.02.21

Turabian Style

Dakam, William, Christine Fernande Nyangono Biyegue, Francoise Raissa Ntentie, and Julius Enyong Oben. 2022. Protective effects of polyphenol-rich extracts of Glyphaea brevis against oxidative stress in streptozotocin-induced diabetic rats. Journal of Complementary Medicine Research, 13 (2), 109-118. doi:10.5455/jcmr.2022.13.02.21

Chicago Style

Dakam, William, Christine Fernande Nyangono Biyegue, Francoise Raissa Ntentie, and Julius Enyong Oben. "Protective effects of polyphenol-rich extracts of Glyphaea brevis against oxidative stress in streptozotocin-induced diabetic rats." Journal of Complementary Medicine Research 13 (2022), 109-118. doi:10.5455/jcmr.2022.13.02.21

MLA (The Modern Language Association) Style

APA (American Psychological Association) Style

Dakam, W., , . C. F. N. B., , . F. R. N. & Oben, . J. E. (2022) Protective effects of polyphenol-rich extracts of Glyphaea brevis against oxidative stress in streptozotocin-induced diabetic rats. Journal of Complementary Medicine Research, 13 (2), 109-118. doi:10.5455/jcmr.2022.13.02.21



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