E-ISSN 2577-5669
 

Original Research 


Efficacy of Sagi (A Persian Medicine-Based Mouth Wash) in Recurrent Aphthous Stomatitis: A Double-Blind Randomized Placebo-Controlled Clinical Trial

Mahdi Adl, Majid Emtiazy, Khatere Kheirollahi.

Abstract
Background: Recurrent aphthous stomatitis (RAS) is a common oral disease. Sagi is one of the natural remedies of traditional Persian medicine that has been used as an antiseptic mouthwash. We designed a randomized, placebo controlled clinical trial to evaluate the efficacy of Sagi in management of RAS.
Material and Methods: In this randomized, double arm, double blind, placebo-controlled clinical trial, 26 patients received Sagi mouthwash as intervention group and 26 patients received placebo as the control group for four consecutive days. Primary outcome measure the pain severity of lesions assessed by visual analogue scale (VAS). The size of the aphthous lesions as another outcome was also measured via millimeter paper.
Results: Regarding within-group changes, a significant decrease was observed in the scores of pain in both group of the study (p<0.05). Moreover, a significant decrease was observed in the size of lesions in Sagi group (p=0.003). However, no such change was seen in the placebo group (p=0.075) (Table 2). According to independent sample t test, there was a significant difference in the mean change of pain score over the study period in the Sagi group compared with the placebo group (p=0.004).
Conclusion: According to the results of this study, it seems that Sagi mouthwash could improve the symptoms of RAS compared to placebo.

Key words: Sagi (a Persian medicine-based mouthwash), Recurrent aphthous stomatitis, Clinical trial.


 
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How to Cite this Article
Pubmed Style

Adl M, Emtiazy M, Kheirollahi K. Efficacy of Sagi (A Persian Medicine-Based Mouth Wash) in Recurrent Aphthous Stomatitis: A Double-Blind Randomized Placebo-Controlled Clinical Trial. J Complement Med Res. 2020; 11(3): 6-10. doi:10.5455/jcmr.2020.11.03.02


Web Style

Adl M, Emtiazy M, Kheirollahi K. Efficacy of Sagi (A Persian Medicine-Based Mouth Wash) in Recurrent Aphthous Stomatitis: A Double-Blind Randomized Placebo-Controlled Clinical Trial. http://www.jocmr.com/?mno=134109 [Access: September 27, 2021]. doi:10.5455/jcmr.2020.11.03.02


AMA (American Medical Association) Style

Adl M, Emtiazy M, Kheirollahi K. Efficacy of Sagi (A Persian Medicine-Based Mouth Wash) in Recurrent Aphthous Stomatitis: A Double-Blind Randomized Placebo-Controlled Clinical Trial. J Complement Med Res. 2020; 11(3): 6-10. doi:10.5455/jcmr.2020.11.03.02



Vancouver/ICMJE Style

Adl M, Emtiazy M, Kheirollahi K. Efficacy of Sagi (A Persian Medicine-Based Mouth Wash) in Recurrent Aphthous Stomatitis: A Double-Blind Randomized Placebo-Controlled Clinical Trial. J Complement Med Res. (2020), [cited September 27, 2021]; 11(3): 6-10. doi:10.5455/jcmr.2020.11.03.02



Harvard Style

Adl, M., Emtiazy, . M. & Kheirollahi, . K. (2020) Efficacy of Sagi (A Persian Medicine-Based Mouth Wash) in Recurrent Aphthous Stomatitis: A Double-Blind Randomized Placebo-Controlled Clinical Trial. J Complement Med Res, 11 (3), 6-10. doi:10.5455/jcmr.2020.11.03.02



Turabian Style

Adl, Mahdi, Majid Emtiazy, and Khatere Kheirollahi. 2020. Efficacy of Sagi (A Persian Medicine-Based Mouth Wash) in Recurrent Aphthous Stomatitis: A Double-Blind Randomized Placebo-Controlled Clinical Trial. Journal of Complementary Medicine Research, 11 (3), 6-10. doi:10.5455/jcmr.2020.11.03.02



Chicago Style

Adl, Mahdi, Majid Emtiazy, and Khatere Kheirollahi. "Efficacy of Sagi (A Persian Medicine-Based Mouth Wash) in Recurrent Aphthous Stomatitis: A Double-Blind Randomized Placebo-Controlled Clinical Trial." Journal of Complementary Medicine Research 11 (2020), 6-10. doi:10.5455/jcmr.2020.11.03.02



MLA (The Modern Language Association) Style

Adl, Mahdi, Majid Emtiazy, and Khatere Kheirollahi. "Efficacy of Sagi (A Persian Medicine-Based Mouth Wash) in Recurrent Aphthous Stomatitis: A Double-Blind Randomized Placebo-Controlled Clinical Trial." Journal of Complementary Medicine Research 11.3 (2020), 6-10. Print. doi:10.5455/jcmr.2020.11.03.02



APA (American Psychological Association) Style

Adl, M., Emtiazy, . M. & Kheirollahi, . K. (2020) Efficacy of Sagi (A Persian Medicine-Based Mouth Wash) in Recurrent Aphthous Stomatitis: A Double-Blind Randomized Placebo-Controlled Clinical Trial. Journal of Complementary Medicine Research, 11 (3), 6-10. doi:10.5455/jcmr.2020.11.03.02