Effect of herbal formulation Sharbat Ahmad Shahi on serum BDNF level in mild to moderate cases of depressive disorder

MOHAMMED YASIR; AHMAD ALI; IRFAN AHMAD; NILOFAR KHAN; MOHAMMAD ZAHID ASHRAF

doi:10.5455/jcmr.2021.12.04.39

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J Complement Med Res. 2021; 12(4): 265-270

doi: 10.5455/jcmr.2021.12.04.39

Effect of herbal formulation Sharbat Ahmad Shahi on serum BDNF level in mild to moderate cases of depressive disorder

MOHAMMED YASIR, AHMAD ALI, IRFAN AHMAD, NILOFAR KHAN, MOHAMMAD ZAHID ASHRAF.

Abstract
Background: Depressive disorder is a common psychiatric condition where suicidal tendency, adverse events of conventional drugs prompt us to find safer yet effective alternative solutions. Traditional Unani formulation Sharbat Ahmad Shahi is used as an antidepressant but needs to be validated along with its scientific mechanism of action. Serum Brain Derived Neurotrophic Factor (BDNF) level is nowadays considered an important biomarker of depression. Hence, we conducted a clinical study to evaluate the effect of Unani formulation in mild to moderate cases of depressive disorders.
Methods: 20 diagnosed cases of depressive disorders (on DSM-V criteria) of mild to moderate intensity having Hamilton Depression Rating Scale score 8-18, were enrolled after informed consent procedure and given Sharbat Ahmad Shahi 20 ml twice daily for 6 weeks during the year 2019. Baseline and post treatment assessments were done using Hamilton Depression Rating Scale, Serum BDNF level and safety parameters.
Result: Highly significant difference was observed between baseline and post treatment Hamilton Depression Rating scale scores and serum BDNF values (p<0.001). However, no significant correlation was observed between these two parameters. Serum BDNF Level was significantly better in cases with full remission in comparison to those who did not remit completely (p<0.05). No serious clinical adverse event was observed in study cases and safety parameters.
Conclusion: Sharbat Ahmad Shahi is a safe and effective antidepressant that improves the serum BDNF level reversing the pathophysiology and hence it may be used as an alternative drug in mild to moderate depressive disorders.

Key words: Depressive disorders; Serum BDNF; antidepressant; Unani medicine; Sharbat Ahmad Shahi

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How to Cite this Article

Pubmed Style

YASIR M, ALI A, AHMAD I, KHAN N, ASHRAF MZ. Effect of herbal formulation Sharbat Ahmad Shahi on serum BDNF level in mild to moderate cases of depressive disorder. J Complement Med Res. 2021; 12(4): 265-270. doi:10.5455/jcmr.2021.12.04.39

Web Style

YASIR M, ALI A, AHMAD I, KHAN N, ASHRAF MZ. Effect of herbal formulation Sharbat Ahmad Shahi on serum BDNF level in mild to moderate cases of depressive disorder. https://www.jocmr.com/?mno=140944 [Access: May 26, 2023]. doi:10.5455/jcmr.2021.12.04.39

AMA (American Medical Association) Style

YASIR M, ALI A, AHMAD I, KHAN N, ASHRAF MZ. Effect of herbal formulation Sharbat Ahmad Shahi on serum BDNF level in mild to moderate cases of depressive disorder. J Complement Med Res. 2021; 12(4): 265-270. doi:10.5455/jcmr.2021.12.04.39

Vancouver/ICMJE Style

YASIR M, ALI A, AHMAD I, KHAN N, ASHRAF MZ. Effect of herbal formulation Sharbat Ahmad Shahi on serum BDNF level in mild to moderate cases of depressive disorder. J Complement Med Res. (2021), [cited May 26, 2023]; 12(4): 265-270. doi:10.5455/jcmr.2021.12.04.39

Harvard Style

YASIR, M., ALI, . A., AHMAD, . I., KHAN, . N. & ASHRAF, . M. Z. (2021) Effect of herbal formulation Sharbat Ahmad Shahi on serum BDNF level in mild to moderate cases of depressive disorder. J Complement Med Res, 12 (4), 265-270. doi:10.5455/jcmr.2021.12.04.39

Turabian Style

YASIR, MOHAMMED, AHMAD ALI, IRFAN AHMAD, NILOFAR KHAN, and MOHAMMAD ZAHID ASHRAF. 2021. Effect of herbal formulation Sharbat Ahmad Shahi on serum BDNF level in mild to moderate cases of depressive disorder. Journal of Complementary Medicine Research, 12 (4), 265-270. doi:10.5455/jcmr.2021.12.04.39

Chicago Style

YASIR, MOHAMMED, AHMAD ALI, IRFAN AHMAD, NILOFAR KHAN, and MOHAMMAD ZAHID ASHRAF. "Effect of herbal formulation Sharbat Ahmad Shahi on serum BDNF level in mild to moderate cases of depressive disorder." Journal of Complementary Medicine Research 12 (2021), 265-270. doi:10.5455/jcmr.2021.12.04.39

MLA (The Modern Language Association) Style

APA (American Psychological Association) Style

YASIR, M., ALI, . A., AHMAD, . I., KHAN, . N. & ASHRAF, . M. Z. (2021) Effect of herbal formulation Sharbat Ahmad Shahi on serum BDNF level in mild to moderate cases of depressive disorder. Journal of Complementary Medicine Research, 12 (4), 265-270. doi:10.5455/jcmr.2021.12.04.39

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