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Phytochemical analysis and in vivo antidirrhoeal potentials of Dialium guineense (Wild) stem bark extract

Gideon Ikechukwu Ogu, Ralphael Amiebenomo.

Cited By: 6

Abstract
This study was undertaken to evaluate the in vivo anti-diarrhoeal activity of methanolic stem bark
extract of Dialium guineense used traditionally as remedy for gastrointestinal disorder in South-
Western Nigeria. The effect of the extract at oral dosesof 50-200 mg/kg body weight on the castor
oil-induced diarrhoea, gastrointestinal motility (charcoal meal) and castor oil-induced intestinal
fluid accumulation (enteropooling) were examined in rats. The extract employed produced a dose dependent
and significant (P<0.05) reduction (32.30 - 80.81%) in the watery nature and
frequency of faecal droppings over 4hours, while loperamide gave 85.81% reduction. On
gastrointestinal motility and enteropoolings, the extract also dose-dependently reduced (P<0.05)
the small intestinal transit of charcoal meal (28.90 - 45.54%) and intestinal fluid volume (46.27 -
73.88%) in amanner comparableto 5mg/kg each of atropine (58.20% motility time inhibition)
and loperamide (76.12% enteropooling inhibition). The acute toxicity and lethality studies on the
extract revealed an oral LD50 value greater than 5000 mg/kg in mice. The phytochemicals detected
in the extract were cardiac glycosides, tannins, phlobatannins, saponins, terpenoids, resins,
steroids/triterpenes, alkaloids, flavonoids, reducing sugars and carbohydrates.The findings from
this study suggest that methanolic extract of D. guineense stem bark possesses antidiarrhoeal
property, probably by anti-secretory mechanism and thus, substantiate the traditional application
of the bark extract in the treatment of diarrhoea in Nigeria.

Key words: Diarrhoea, Dialium guineense, intestinal transit, antisecretory, loperamide


 
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How to Cite this Article
Pubmed Style

Gideon Ikechukwu Ogu, Ralphael Amiebenomo. Phytochemical analysis and in vivo antidirrhoeal potentials of Dialium guineense (Wild) stem bark extract. J Complement Med Res. 2012; 1(2): 105-110. doi:10.5455/jice.20120715061917

Web Style

Gideon Ikechukwu Ogu, Ralphael Amiebenomo. Phytochemical analysis and in vivo antidirrhoeal potentials of Dialium guineense (Wild) stem bark extract. https://www.jocmr.com/?mno=22035 [Access: May 26, 2023]. doi:10.5455/jice.20120715061917

AMA (American Medical Association) Style

Gideon Ikechukwu Ogu, Ralphael Amiebenomo. Phytochemical analysis and in vivo antidirrhoeal potentials of Dialium guineense (Wild) stem bark extract. J Complement Med Res. 2012; 1(2): 105-110. doi:10.5455/jice.20120715061917


Vancouver/ICMJE Style

Gideon Ikechukwu Ogu, Ralphael Amiebenomo. Phytochemical analysis and in vivo antidirrhoeal potentials of Dialium guineense (Wild) stem bark extract. J Complement Med Res. (2012), [cited May 26, 2023]; 1(2): 105-110. doi:10.5455/jice.20120715061917


Harvard Style

Gideon Ikechukwu Ogu, Ralphael Amiebenomo (2012) Phytochemical analysis and in vivo antidirrhoeal potentials of Dialium guineense (Wild) stem bark extract. J Complement Med Res, 1 (2), 105-110. doi:10.5455/jice.20120715061917


Turabian Style

Gideon Ikechukwu Ogu, Ralphael Amiebenomo. 2012. Phytochemical analysis and in vivo antidirrhoeal potentials of Dialium guineense (Wild) stem bark extract. Journal of Complementary Medicine Research, 1 (2), 105-110. doi:10.5455/jice.20120715061917


Chicago Style

Gideon Ikechukwu Ogu, Ralphael Amiebenomo. "Phytochemical analysis and in vivo antidirrhoeal potentials of Dialium guineense (Wild) stem bark extract." Journal of Complementary Medicine Research 1 (2012), 105-110. doi:10.5455/jice.20120715061917


MLA (The Modern Language Association) Style

Gideon Ikechukwu Ogu, Ralphael Amiebenomo. "Phytochemical analysis and in vivo antidirrhoeal potentials of Dialium guineense (Wild) stem bark extract." Journal of Complementary Medicine Research 1.2 (2012), 105-110. Print. doi:10.5455/jice.20120715061917


APA (American Psychological Association) Style

Gideon Ikechukwu Ogu, Ralphael Amiebenomo (2012) Phytochemical analysis and in vivo antidirrhoeal potentials of Dialium guineense (Wild) stem bark extract. Journal of Complementary Medicine Research, 1 (2), 105-110. doi:10.5455/jice.20120715061917


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