E-ISSN 2577-5669
 

Research Article 


Anticancer Activity of Cassia Oleoresin Mediated Selenium Nanoparticles Against Lung Cancer Cell Line

G. PREETHI, ANITHA ROY, RAGHUNANDHAKUMAR, S. RAJESHKUMAR, LAKSHMI T.

Abstract
Introduction: Selenium nanoparticles (SeNPs) have various advantages over different nanomaterials due to the promising role of selenium within the
stabilization of the system and activation of the defense response. The utilization of SeNPs and their supplements solely have pharmacological significance. Cassia oleoresin helps to prevent nausea, prediabetes, diarrhoea, infections, loss of appetite, chest pain and kidney disorders.
Aim: Aim of the present study was to determine the anti-cancer activity of cassia oleoresin mediated selenium nanoparticles against lung cancer cell lines.
Materials and Methods: Plant extract, cassia oleoresin was obtained from Synthite industries pvt limited, Kerala. The cytotoxic effects of cassia oleoresin were assessed on A549 cells. Cells were treated with different concentrations of cassia oleoresin (10, 20, 40, 60, 80, 100µg/ml) for 24 hours and cell viability was evaluated by MTT assay.
Results: The cassia oleoresin caused a dose dependent increase in cytotoxicity in the A549 cell line. The maximum cytotoxic effect was noticed with the maximum dose used in the study (ie) 100µg/ml. Thus cassia oleoresin demonstrated good anticancer activity against lung cancer cell lines.
Conclusion: The study results depicted that the IC50 value was 15µg/ml almost half of the viable cells were destroyed. Thus it was evident that cassia oleoresin possesses good anticancer activity. However more research is needed to understand the mechanism of cytotoxicity of the extract .

Key words: selenium nanoparticles ; cassia oleoresin ; A549 cells ; MTT assay ; cytotoxicity ,eco friendly, green synthesis


 
ARTICLE TOOLS
Abstract
PDF Fulltext
How to cite this articleHow to cite this article
Citation Tools
Related Records
 Articles by G. PREETHI
Articles by ANITHA ROY
Articles by RAGHUNANDHAKUMAR
Articles by S. RAJESHKUMAR
Articles by LAKSHMI T
on Google
on Google Scholar


REFERENCES
1. Özarmagan S, Bozbora A. Obezitenin Tanimive Temel Bilgiler. Y Orhan, A Bozbora (Eds.), Obezite, Ýstanbul, Medikal Yayincilik, 2008, s.289-301.
2. Kolotkin RL, Meter K,Williams GR. Quality of life and obesity. Obesity Reviews 2001; 2:219-229. [DOI via Crossref]    [Pubmed]   
3. Kushner R, Foster G. Obesity and quality of life. Nutrition 2000; 10:947-952.
4. Satman Ý, Yilmaz T, Þengul A, Salman S, Salman F, Uygur S, ve ark. Population based study of diabetes and risk characteristics in Turkey: Results of Turkish diabetes epidemiology study (TURDEP). Diabetes Care 2002; 25:1551-1556. [DOI via Crossref]   
5. Hatemi H, Turan N, Arik N, Yumuk V. Turkiye obezite ve hipertansiyon taramasisonuçlari(TOHTA). Endokrinolojide Yoneliþler Dergisi 2002; 11(Ek-1):11-16.
6. turendokrin.org TURDEP II Sonuçlari. [08.06.2012] www.turendokrin.org
7. Niero M, Martin M, Finger T, Lucas R, Mear I, Wild D, et al. A new approach to multicultural item generation in the development of two obesity-specific measures: The Obesity and Weight Loss Quality of Life (OWLQOL) Questionnaire and the Weight-Related Symptom Measure (WRSM). Clinical Therapeutics 2002; 24:690-700. [DOI via Crossref]   
8. Fontaine KR, Barofsky I. Obesity and healthrelated quality of life. Obesity Review 2001; 2:173-182. [DOI via Crossref]   
9. Zwaan M, Petersen I, Kaerber M, Burgmer R, Nolting B, et al. Obesity and quality of life: a controlled study of normal-weight and obese individuals. Psychosomatics 2009; 50:474-482. [DOI via Crossref]   
10. Myers A, Rosen J. Obesity stigmatization and coping: Relation to mental health symptoms, body image and self esteem. International Journal of Obesity 1999; 23:221-230. [DOI via Crossref]   
11. Yilmaz E, Eser E, Gurgun C, Kultursay H. Kronik Kalp Yetersizligi Anketi'nin (KKYA) Turkçe surumunun geçerlilik ve guvenilirligi. Anadolu Kardiyoloji Dergisi 2010; 10:526-538.
12. Eser E. Saglikla ilgili yaþam kalitesi olçeklerinin kulturel uyarlanmasi. Saglikta Birikim 2006; 21:6-8.
13. Kolotkin, RL, Crosby RD, Kosloski KD, Williams GR. Development of a Brief Measure to Assess Quality of Life in Obesity Research 2001; 9:102-111.
14. Duval K, Marceau P, Pérusse L, Lacasse Y. An overview of obesity-specific quality of life in questionnaires. Obesity Reviews 2006; 7:347-360. [DOI via Crossref]    [Pubmed]   
15. Akgul A. Tibbi Araþtirmalarda Ýstatiksel Analiz Teknikleri. Ankara: Yuksekogretim Kurulu Matbaasi, 1997, s.169-178, 492-586.
16. Patrick LD, Bushnell DM. Obesity-Specific Patient Reported Outcomes: Obesity and Weight Loss Quality of Life (OWLQOL) and WeightRelated Symptoms Measure (WRSM). User’s Manual and Scoring Diskette for United States Version. Washington, Seattle University of Washington, 2004, p.1-45.
17. Patrick LD, Bushnell DM, Rothman M. Performance of two self-report measures for evaluating obesity and weight loss. Obesity Research 2004; 2:48-57. [DOI via Crossref]    [Pubmed]   
18. Aydemir Ö. Konsultasyon-liyezon psikiyatrisinde yaþam kalitesi olçumu: Kisa Form 36 (SF-36). 3P Dergisi 1999; 7:14-23.
19. Mapi-instiute.com. http://www.mapiinstitute.com/home (Eriþim Tarihi : 2012)
20. Aksayan S, Gozum S.KulturlerarasiÖlçek Uyarlanmasiiçin Rehber I: Ölçek Uyarlama ve Aþamalarive Dil Uyarlamasi. Hemþirelik Araþtirma Degisi 2002; 4:9-14.
21. Karasar N. Bilimsel Araþtirma Yontemi. Yedinci basim, Ankara: Sim Matbaasi, 1995, s.147-153.
22. Tavþancil E. Tutumlarin Ölçulmesi ve SPSS ile Veri Analizi. Üçuncu baski, Ankara: Nobel Yayinlari, 2006, s.16-58, 202-208.

How to Cite this Article
Pubmed Style

G. PREETHI, ANITHA ROY, RAGHUNANDHAKUMAR, S. RAJESHKUMAR, LAKSHMI T. Anticancer Activity of Cassia Oleoresin Mediated Selenium Nanoparticles Against Lung Cancer Cell Line. J Complement Med Res. 2021; 12(3): 138-143. doi:10.5455/jcmr.2021.12.03.18


Web Style

G. PREETHI, ANITHA ROY, RAGHUNANDHAKUMAR, S. RAJESHKUMAR, LAKSHMI T. Anticancer Activity of Cassia Oleoresin Mediated Selenium Nanoparticles Against Lung Cancer Cell Line. https://www.jocmr.com/?mno=35950 [Access: November 03, 2022]. doi:10.5455/jcmr.2021.12.03.18


AMA (American Medical Association) Style

G. PREETHI, ANITHA ROY, RAGHUNANDHAKUMAR, S. RAJESHKUMAR, LAKSHMI T. Anticancer Activity of Cassia Oleoresin Mediated Selenium Nanoparticles Against Lung Cancer Cell Line. J Complement Med Res. 2021; 12(3): 138-143. doi:10.5455/jcmr.2021.12.03.18



Vancouver/ICMJE Style

G. PREETHI, ANITHA ROY, RAGHUNANDHAKUMAR, S. RAJESHKUMAR, LAKSHMI T. Anticancer Activity of Cassia Oleoresin Mediated Selenium Nanoparticles Against Lung Cancer Cell Line. J Complement Med Res. (2021), [cited November 03, 2022]; 12(3): 138-143. doi:10.5455/jcmr.2021.12.03.18



Harvard Style

G. PREETHI, ANITHA ROY, RAGHUNANDHAKUMAR, S. RAJESHKUMAR, LAKSHMI T (2021) Anticancer Activity of Cassia Oleoresin Mediated Selenium Nanoparticles Against Lung Cancer Cell Line. J Complement Med Res, 12 (3), 138-143. doi:10.5455/jcmr.2021.12.03.18



Turabian Style

G. PREETHI, ANITHA ROY, RAGHUNANDHAKUMAR, S. RAJESHKUMAR, LAKSHMI T. 2021. Anticancer Activity of Cassia Oleoresin Mediated Selenium Nanoparticles Against Lung Cancer Cell Line. Journal of Complementary Medicine Research, 12 (3), 138-143. doi:10.5455/jcmr.2021.12.03.18



Chicago Style

G. PREETHI, ANITHA ROY, RAGHUNANDHAKUMAR, S. RAJESHKUMAR, LAKSHMI T. "Anticancer Activity of Cassia Oleoresin Mediated Selenium Nanoparticles Against Lung Cancer Cell Line." Journal of Complementary Medicine Research 12 (2021), 138-143. doi:10.5455/jcmr.2021.12.03.18



MLA (The Modern Language Association) Style

G. PREETHI, ANITHA ROY, RAGHUNANDHAKUMAR, S. RAJESHKUMAR, LAKSHMI T. "Anticancer Activity of Cassia Oleoresin Mediated Selenium Nanoparticles Against Lung Cancer Cell Line." Journal of Complementary Medicine Research 12.3 (2021), 138-143. Print. doi:10.5455/jcmr.2021.12.03.18



APA (American Psychological Association) Style

G. PREETHI, ANITHA ROY, RAGHUNANDHAKUMAR, S. RAJESHKUMAR, LAKSHMI T (2021) Anticancer Activity of Cassia Oleoresin Mediated Selenium Nanoparticles Against Lung Cancer Cell Line. Journal of Complementary Medicine Research, 12 (3), 138-143. doi:10.5455/jcmr.2021.12.03.18