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2022, Vol: 13, Issue: 4
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Research Article 


Design and characterization of Tacrolimus monohydrate loaded core shell lipid polymer hybrid nanoparticle

Hussein Abdelamir Mohammad, Mowafaq M Ghareeb, Mohammd Akrami, Ameer Sabah Sahib.

Abstract
Tacrolimus monohydrate (TAC) loaded core shell lipid polymer hybrid nanoparticle (CS-LPHNs) composed of polymer core (PLGA) surrounded by lipid shell (lecithin). DSPE-PEG2000 was used as stabilize the nanoparticles. TAC-CS-LPHNs were prepared by single step modified nanoprecipitation method. Field emission electron microscope and Transmission Electron Microscope reveals a spherical shape nano-sized particle coated with a lipid layer. The nanoparticles ranged in size from 82nm±0.2-195±0.143nm which increase with increase the polymer quantity. The entrapment efficiency also affected by the polymer quantity that ranges from 55±1.23%-76±1.93%. XRD and DSC studies show conversion of TAC from crystalline into amorphous when imbedded inside the CS-LPHNs and FTIR study shows no chemical interaction between TAC and other components. The Cytotoxicity study of TAC and TAC-CS-LPHNs show a decrease in cytotoxicity of loaded TAC (IC50=1.18067±0.045µg/ml) in compare with free TAC(IC50=0.697±0.02µg/ml). Finally, the uptake study shows complete internalization of nanoparticle by Vero cell and accumulation of nanoparticles inside nucleus and cytoplasm. The results suggested CS-LPHNs is a good drug delivery system for TAC which is safe, effective and promising a better clinicals outcome.

Key words: lipid polymer hybrid, Tacrolimus monohydrate, IC50, PLGA, Lecithin, LPHNs.


 
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How to Cite this Article
Pubmed Style

Hussein Abdelamir Mohammad, Mowafaq M Ghareeb, Mohammd Akrami, Ameer Sabah Sahib. Design and characterization of Tacrolimus monohydrate loaded core shell lipid polymer hybrid nanoparticle. J Complement Med Res. 2020; 11(5): 204-214.

Web Style

Hussein Abdelamir Mohammad, Mowafaq M Ghareeb, Mohammd Akrami, Ameer Sabah Sahib. Design and characterization of Tacrolimus monohydrate loaded core shell lipid polymer hybrid nanoparticle. https://www.jocmr.com/?mno=74069 [Access: January 27, 2023].

AMA (American Medical Association) Style

Hussein Abdelamir Mohammad, Mowafaq M Ghareeb, Mohammd Akrami, Ameer Sabah Sahib. Design and characterization of Tacrolimus monohydrate loaded core shell lipid polymer hybrid nanoparticle. J Complement Med Res. 2020; 11(5): 204-214.


Vancouver/ICMJE Style

Hussein Abdelamir Mohammad, Mowafaq M Ghareeb, Mohammd Akrami, Ameer Sabah Sahib. Design and characterization of Tacrolimus monohydrate loaded core shell lipid polymer hybrid nanoparticle. J Complement Med Res. (2020), [cited January 27, 2023]; 11(5): 204-214.


Harvard Style

Hussein Abdelamir Mohammad, Mowafaq M Ghareeb, Mohammd Akrami, Ameer Sabah Sahib (2020) Design and characterization of Tacrolimus monohydrate loaded core shell lipid polymer hybrid nanoparticle. J Complement Med Res, 11 (5), 204-214.


Turabian Style

Hussein Abdelamir Mohammad, Mowafaq M Ghareeb, Mohammd Akrami, Ameer Sabah Sahib. 2020. Design and characterization of Tacrolimus monohydrate loaded core shell lipid polymer hybrid nanoparticle. Journal of Complementary Medicine Research, 11 (5), 204-214.


Chicago Style

Hussein Abdelamir Mohammad, Mowafaq M Ghareeb, Mohammd Akrami, Ameer Sabah Sahib. "Design and characterization of Tacrolimus monohydrate loaded core shell lipid polymer hybrid nanoparticle." Journal of Complementary Medicine Research 11 (2020), 204-214.


MLA (The Modern Language Association) Style

Hussein Abdelamir Mohammad, Mowafaq M Ghareeb, Mohammd Akrami, Ameer Sabah Sahib. "Design and characterization of Tacrolimus monohydrate loaded core shell lipid polymer hybrid nanoparticle." Journal of Complementary Medicine Research 11.5 (2020), 204-214. Print.


APA (American Psychological Association) Style

Hussein Abdelamir Mohammad, Mowafaq M Ghareeb, Mohammd Akrami, Ameer Sabah Sahib (2020) Design and characterization of Tacrolimus monohydrate loaded core shell lipid polymer hybrid nanoparticle. Journal of Complementary Medicine Research, 11 (5), 204-214.


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