Biosynthesis Of Selenium Nanoparticles Using Cassia Oleoresin and Its Anticancer Activity Against Liver Cancer Cell Lines

SRIVATCHAVA. S; ANITHA ROY; S. Rajesh kumar; S. RAGHUNANDHAKUMAR; LAKSHMI THANGAVELU

doi:10.5455/jcmr.2021.12.04.07

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J Complement Med Res. 2021; 12(4): 48-54

doi: 10.5455/jcmr.2021.12.04.07

Biosynthesis Of Selenium Nanoparticles Using Cassia Oleoresin and Its Anticancer Activity Against Liver Cancer Cell Lines

SRIVATCHAVA. S, ANITHA ROY, S. Rajesh kumar, S. RAGHUNANDHAKUMAR, LAKSHMI THANGAVELU.

Abstract
Introduction: Cassia is scientifically known as Cinnamomum Cassia, and it is a member of the Lauraceae family. Cassia is the botanical name for the Cassia bark. Cassia cinnamon is also used for chest pain, high blood pressure, kidney disorders, cramps, and cancer.
Aim: The present study was designed to analyse the anticancer activity of cassia oleoresin mediated selenium nanoparticles in HepG2 liver cancer cell line.
Materials And Method: Cassia oleoresin was obtained from synthite industries Ltd,Kerala. MTT assay was performed using HEPG2 cell lines to asses the anticancer activity.The HEPG2 cell were treated with different concentration of cassia oleoresin mediated selenium nanoparticle (20,40,60,80,100,200μg/ml) for 24 hours and the cell viability was analysed .
Results: The results of MTT assay showed a dose dependent decrease in cell viability of cassia oleoresin mediated selenium nanoparticle against the HEPG2 liver cancer cell line.In the HepG2 cell line, the oleoresin induced selenium increased cytotoxicity in a dose-dependent manner. The maximum cytotoxic effect was observed at a dose of 200μg/ml, which was used in the study.The IC50 value was 15μg/ml.
Conclusion: The present study within the limitations conclude that cassia oleoresin mediated selenium nanoparticles possess a good level of cytotoxic activity against HEPG2 cell lines. Hence the extract may be further explored in animal models to establish its activity

Key words: Anti-cancer ; oleoresin ; MTT assay ; HEPG2 cells ; Selenium nanoparticle, green technique, eco-friendly

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Pubmed Style

SRIVATCHAVA. S, ANITHA ROY, S. Rajesh kumar, S. RAGHUNANDHAKUMAR, LAKSHMI THANGAVELU. Biosynthesis Of Selenium Nanoparticles Using Cassia Oleoresin and Its Anticancer Activity Against Liver Cancer Cell Lines. J Complement Med Res. 2021; 12(4): 48-54. doi:10.5455/jcmr.2021.12.04.07

Web Style

SRIVATCHAVA. S, ANITHA ROY, S. Rajesh kumar, S. RAGHUNANDHAKUMAR, LAKSHMI THANGAVELU. Biosynthesis Of Selenium Nanoparticles Using Cassia Oleoresin and Its Anticancer Activity Against Liver Cancer Cell Lines. https://www.jocmr.com/?mno=35960 [Access: August 07, 2022]. doi:10.5455/jcmr.2021.12.04.07

AMA (American Medical Association) Style

SRIVATCHAVA. S, ANITHA ROY, S. Rajesh kumar, S. RAGHUNANDHAKUMAR, LAKSHMI THANGAVELU. Biosynthesis Of Selenium Nanoparticles Using Cassia Oleoresin and Its Anticancer Activity Against Liver Cancer Cell Lines. J Complement Med Res. 2021; 12(4): 48-54. doi:10.5455/jcmr.2021.12.04.07

Vancouver/ICMJE Style

SRIVATCHAVA. S, ANITHA ROY, S. Rajesh kumar, S. RAGHUNANDHAKUMAR, LAKSHMI THANGAVELU. Biosynthesis Of Selenium Nanoparticles Using Cassia Oleoresin and Its Anticancer Activity Against Liver Cancer Cell Lines. J Complement Med Res. (2021), [cited August 07, 2022]; 12(4): 48-54. doi:10.5455/jcmr.2021.12.04.07

Harvard Style

SRIVATCHAVA. S, ANITHA ROY, S. Rajesh kumar, S. RAGHUNANDHAKUMAR, LAKSHMI THANGAVELU (2021) Biosynthesis Of Selenium Nanoparticles Using Cassia Oleoresin and Its Anticancer Activity Against Liver Cancer Cell Lines. J Complement Med Res, 12 (4), 48-54. doi:10.5455/jcmr.2021.12.04.07

Turabian Style

SRIVATCHAVA. S, ANITHA ROY, S. Rajesh kumar, S. RAGHUNANDHAKUMAR, LAKSHMI THANGAVELU. 2021. Biosynthesis Of Selenium Nanoparticles Using Cassia Oleoresin and Its Anticancer Activity Against Liver Cancer Cell Lines. Journal of Complementary Medicine Research, 12 (4), 48-54. doi:10.5455/jcmr.2021.12.04.07

Chicago Style

SRIVATCHAVA. S, ANITHA ROY, S. Rajesh kumar, S. RAGHUNANDHAKUMAR, LAKSHMI THANGAVELU. "Biosynthesis Of Selenium Nanoparticles Using Cassia Oleoresin and Its Anticancer Activity Against Liver Cancer Cell Lines." Journal of Complementary Medicine Research 12 (2021), 48-54. doi:10.5455/jcmr.2021.12.04.07

MLA (The Modern Language Association) Style

APA (American Psychological Association) Style

SRIVATCHAVA. S, ANITHA ROY, S. Rajesh kumar, S. RAGHUNANDHAKUMAR, LAKSHMI THANGAVELU (2021) Biosynthesis Of Selenium Nanoparticles Using Cassia Oleoresin and Its Anticancer Activity Against Liver Cancer Cell Lines. Journal of Complementary Medicine Research, 12 (4), 48-54. doi:10.5455/jcmr.2021.12.04.07



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