E-ISSN 2577-5669
 

Research Article 


Free Radical Scavenging and Cytotoxic Effect of Copper Nanoparticles Synthesised Using Nutmeg Oleoresin

TRISHA SASIKUMAR, ANITHA ROY, S. RAJESHKUMAR, LAKSHMI THANGAVELU.

Abstract
Background: Copper nanoparticles that are extremely small and have a high surface to volume ratio can also serve as antifungal/antibacterial agents. They have excellent biocompatibility, are economical, and exhibit low toxicity. Nutmeg or Myristica fragrans is found to have health benefits, including its ability to relieve pain, soothe indigestion, strengthen cognitive function, detoxify the body, boost skin health, alleviate oral conditions, reduce insomnia, increase immune system function, and prevent leukemia, and improve blood circulation.
Aim: The aim of this study was to analyse the free radical scavenging and cytotoxic activities of copper nanoparticles made from nutmeg oleoresin.
Materials and methods: In this study, nutmeg oleoresin was used to synthesise copper nanoparticles. These nanoparticles were subjected to cytotoxic and free radical scavenging assays. The cytotoxicity was studied by brine shrimp lethality assay and the free radical scavenging activity by DPPH assay technique.
Results: The extract shows the highest percentage of live nauplii at 50% for 80μL concentration and antioxidant activity was 84% almost close to the standard at 50μL concentration.
Conclusion: The extract has shown high cytotoxicity and good free radical scavenging with increase in concentration. It also showed good antioxidant activity with DPPH assay. Hence , nutmeg mediated copper nanoparticles may be used in the treatment of cancer and other conditions such as diabetes and cardiovascular disease.

Key words: Copper nanoparticles, Nutmeg oleoresin, cytotoxic activity , free radical scavenging activity, green synthesis, eco friendly


 
ARTICLE TOOLS
Abstract
PDF Fulltext
How to cite this articleHow to cite this article
Citation Tools
Related Records
 Articles by TRISHA SASIKUMAR
Articles by ANITHA ROY
Articles by S. RAJESHKUMAR
Articles by LAKSHMI THANGAVELU
on Google
on Google Scholar


REFERENCES
1. Helvig D, Bauer LB, Riegel T, Schmidek HH, Sweet WH. Operative Neurosurgical Techniques. Forth ed.,Philadelphia, WB Saunders, 2000, p.513-517.
2. Mesulam MM. Principiles of Behavioral and Cognitive Neurology. Second ed., New York, Oxford University Press, 2000, p.82-83.
3. Wong CW, Ko SF, Wai YY. Arachnoid cyst of the lateral ventricule manifesting positional psychosis. Neurosurgery 1993; 32:841-843. [DOI via Crossref]    [Pubmed]   
4. Hodges JR. Pure apraxic agraphia with recovery after drainage of left frontal cyst. Cortex 1991; 27:469-473. [DOI via Crossref]   
5. Relkin N, Plum F, Mattis S, Eidelberg D, Jranel D. Impulsive homicide associated with arachnoid cyst and unilateral frontotemporal cerebral disfunction. Semin Neuropsychiatry 1996; 1:172-183.
6. Lanczik M, Fritze J, Classen W, Ihl R, Maurer K. Schizophrenia like psychosis associated with an arachnoid cyst visualized by mapping of EEG and P300. Psychiatry Res 1989; 29:421-423. [DOI via Crossref]   
7. Tsurushima H, Harakuri T, Saito A, Tominaga D, Hyodo A, Yoshii Y. Symptomatic arachnoid cyst of left frontal convexity presenting memory disturbance. Neurol Med Chir 2000; 40:339-341. [DOI via Crossref]   
8. Choi.UC, Kim SD. Pathogenesis of arachnoid cyst: Congenital or traumatic? Pediatric Neurosurgery 1998;29:260-266.
9. Yalcin AD, Öncel C, Kaymaz A, Kuloglu N, Forta H. Evidence against association between arachnoid cysts and epilepsy. Epilepsy Res 2002; 49:255-260 [DOI via Crossref]   
10. Kuhnley EJ, White DH, Granoff AL. Psychiatric presentation of an arachnoid cyst. J CIin Psychiatry 1981; 42:167-168.

How to Cite this Article
Pubmed Style

TRISHA SASIKUMAR, ANITHA ROY, S. RAJESHKUMAR, LAKSHMI THANGAVELU. Free Radical Scavenging and Cytotoxic Effect of Copper Nanoparticles Synthesised Using Nutmeg Oleoresin. J Complement Med Res. 2021; 12(4): 68-73. doi:10.5455/jcmr.2021.12.04.10


Web Style

TRISHA SASIKUMAR, ANITHA ROY, S. RAJESHKUMAR, LAKSHMI THANGAVELU. Free Radical Scavenging and Cytotoxic Effect of Copper Nanoparticles Synthesised Using Nutmeg Oleoresin. https://www.jocmr.com/?mno=35964 [Access: August 07, 2022]. doi:10.5455/jcmr.2021.12.04.10


AMA (American Medical Association) Style

TRISHA SASIKUMAR, ANITHA ROY, S. RAJESHKUMAR, LAKSHMI THANGAVELU. Free Radical Scavenging and Cytotoxic Effect of Copper Nanoparticles Synthesised Using Nutmeg Oleoresin. J Complement Med Res. 2021; 12(4): 68-73. doi:10.5455/jcmr.2021.12.04.10



Vancouver/ICMJE Style

TRISHA SASIKUMAR, ANITHA ROY, S. RAJESHKUMAR, LAKSHMI THANGAVELU. Free Radical Scavenging and Cytotoxic Effect of Copper Nanoparticles Synthesised Using Nutmeg Oleoresin. J Complement Med Res. (2021), [cited August 07, 2022]; 12(4): 68-73. doi:10.5455/jcmr.2021.12.04.10



Harvard Style

TRISHA SASIKUMAR, ANITHA ROY, S. RAJESHKUMAR, LAKSHMI THANGAVELU (2021) Free Radical Scavenging and Cytotoxic Effect of Copper Nanoparticles Synthesised Using Nutmeg Oleoresin. J Complement Med Res, 12 (4), 68-73. doi:10.5455/jcmr.2021.12.04.10



Turabian Style

TRISHA SASIKUMAR, ANITHA ROY, S. RAJESHKUMAR, LAKSHMI THANGAVELU. 2021. Free Radical Scavenging and Cytotoxic Effect of Copper Nanoparticles Synthesised Using Nutmeg Oleoresin. Journal of Complementary Medicine Research, 12 (4), 68-73. doi:10.5455/jcmr.2021.12.04.10



Chicago Style

TRISHA SASIKUMAR, ANITHA ROY, S. RAJESHKUMAR, LAKSHMI THANGAVELU. "Free Radical Scavenging and Cytotoxic Effect of Copper Nanoparticles Synthesised Using Nutmeg Oleoresin." Journal of Complementary Medicine Research 12 (2021), 68-73. doi:10.5455/jcmr.2021.12.04.10



MLA (The Modern Language Association) Style

TRISHA SASIKUMAR, ANITHA ROY, S. RAJESHKUMAR, LAKSHMI THANGAVELU. "Free Radical Scavenging and Cytotoxic Effect of Copper Nanoparticles Synthesised Using Nutmeg Oleoresin." Journal of Complementary Medicine Research 12.4 (2021), 68-73. Print. doi:10.5455/jcmr.2021.12.04.10



APA (American Psychological Association) Style

TRISHA SASIKUMAR, ANITHA ROY, S. RAJESHKUMAR, LAKSHMI THANGAVELU (2021) Free Radical Scavenging and Cytotoxic Effect of Copper Nanoparticles Synthesised Using Nutmeg Oleoresin. Journal of Complementary Medicine Research, 12 (4), 68-73. doi:10.5455/jcmr.2021.12.04.10