E-ISSN 2577-5669
 

Research Article 


Genotoxicity potentials of methanolic extracts of Mimosa pudica against oral cancer cells

Dharahaas C, Lakshmi T, Anitha Roy, Raghunandhakumar. S.

Abstract
To study the genotoxic potentials of methanolic extracts of mimosa pud is against oral cancer cells. Oral cancer also called as mouth cancer is type of head and neck cancer and is cancerous tissue growth located in oral cavity It may arise as a primary lesion originating in any of the tissues in the mouth, by metastasis from a distant site of origin, or by extension from a neighboring anatomic structure, such as the nasal cavity. Alternatively, the oral cancers may originate in any of the tissues of the mouth, and may be of varied histologic types: teratoma, adenocarcinoma derived from a major or minor salivary gland, lymphoma from tonsillar or other lymphoid tissue, or melanoma from the pigment-producing cells of the oral mucosa. Cells were maintained in DMEM medium, supplemented with 10% Fetal Bovine Serum, at 37oC in a humidified atmosphere with 5% CO2. The cells were plated in 96 well flat bottom tissue culture plates at a density of approximately 1.2X 104 cells /well and allowed to attach overnight at 37oC. The medium was then discarded and cells were incubated with different concentrations of the samples (100, 200 & 300 g) for 24 hours. The cell suspension was then collected and subjected to DNA isolation procedures. The methanolic extracts of M. pudica show anticancer activity on cancer activity on oral cancer cells. Here DNA fragmentation is done where more fragmentation is seen with dosage increased. So this proves that extracts show anticancer activity. Our study shows that the extracts which we used show anti cancer activity against oral cancer cells

Key words: Genotoxic potential, Mimosa Pudica, DNA Fragmentation, DMEM medium, Gel electrophoresis


 
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How to Cite this Article
Pubmed Style

Dharahaas C, Lakshmi T, Anitha Roy, Raghunandhakumar. S. Genotoxicity potentials of methanolic extracts of Mimosa pudica against oral cancer cells. J Complement Med Res. 2020; 11(5): 24-29.


Web Style

Dharahaas C, Lakshmi T, Anitha Roy, Raghunandhakumar. S. Genotoxicity potentials of methanolic extracts of Mimosa pudica against oral cancer cells. http://www.jocmr.com/?mno=63686 [Access: March 22, 2021].


AMA (American Medical Association) Style

Dharahaas C, Lakshmi T, Anitha Roy, Raghunandhakumar. S. Genotoxicity potentials of methanolic extracts of Mimosa pudica against oral cancer cells. J Complement Med Res. 2020; 11(5): 24-29.



Vancouver/ICMJE Style

Dharahaas C, Lakshmi T, Anitha Roy, Raghunandhakumar. S. Genotoxicity potentials of methanolic extracts of Mimosa pudica against oral cancer cells. J Complement Med Res. (2020), [cited March 22, 2021]; 11(5): 24-29.



Harvard Style

Dharahaas C, Lakshmi T, Anitha Roy, Raghunandhakumar. S (2020) Genotoxicity potentials of methanolic extracts of Mimosa pudica against oral cancer cells. J Complement Med Res, 11 (5), 24-29.



Turabian Style

Dharahaas C, Lakshmi T, Anitha Roy, Raghunandhakumar. S. 2020. Genotoxicity potentials of methanolic extracts of Mimosa pudica against oral cancer cells. Journal of Complementary Medicine Research, 11 (5), 24-29.



Chicago Style

Dharahaas C, Lakshmi T, Anitha Roy, Raghunandhakumar. S. "Genotoxicity potentials of methanolic extracts of Mimosa pudica against oral cancer cells." Journal of Complementary Medicine Research 11 (2020), 24-29.



MLA (The Modern Language Association) Style

Dharahaas C, Lakshmi T, Anitha Roy, Raghunandhakumar. S. "Genotoxicity potentials of methanolic extracts of Mimosa pudica against oral cancer cells." Journal of Complementary Medicine Research 11.5 (2020), 24-29. Print.



APA (American Psychological Association) Style

Dharahaas C, Lakshmi T, Anitha Roy, Raghunandhakumar. S (2020) Genotoxicity potentials of methanolic extracts of Mimosa pudica against oral cancer cells. Journal of Complementary Medicine Research, 11 (5), 24-29.